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Journal article

Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance

Hennequart, Marc[UCL] Pilotte, Luc Cane, Stefania Hoffmann, Delia[UCL] Stroobant, Vincent De Plaen, Etienne[UCL] Van den Eynde, Benoît[UCL] (2017) Cancer Immunology Research — Vol. 5, no. 8, p. 695-709 (2017)

Journal article

Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937.

Hoffmann, Delia[UCL] Pilotte, Luc[UCL] Stroobant, Vincent[UCL] Van den Eynde, Benoît[UCL] (2019) International journal of tryptophan research : IJTR — Vol. 12, no.1, p. 1178646919891736 (2019)

Journal article

Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues

Théate, Ivan[UCL] van Baren, Nicolas[UCL] Pilotte, Luc Moulin, Pierre Larrieu, Pierre[UCL] Renauld, Jean-Christophe[UCL] Hervé, Caroline[UCL] Gutierrez-Roelens, Ilse[UCL] Marbaix, Etienne[UCL] Sempoux, Christine[UCL] Van den Eynde, Benoît[UCL] (2015) Cancer Immunology Research — Vol. 3, no. 2, p. 161-72 (2015)

Journal article

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Uyttenhove, Catherine[UCL] Pilotte, Luc[UCL] Théate, Ivan[UCL] Stroobant, Vincent[UCL] Colau, Didier[UCL] Parmentier, Nicolas[UCL] Boon, Thierry[UCL] Van den Eynde, Benoît[UCL] (2003) Nature Medicine — Vol. 9, no. 10, p. 1269-1274 (2003)

Journal article

IDO1 and TDO inhibitory evaluation of analogues of the marine pyrroloiminoquinone alkaloids: Wakayin and Tsitsikammamines.

Levy, Thomas Marchand, Laura Stroobant, Vincent Pilotte, Luc Van den Eynde, Benoît[UCL] Rodriguez, Frédéric Delfourne, Evelyne (2021) Bioorganic & medicinal chemistry letters — Vol. 40, p. 127910 (2021)

Journal article

TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism.

Canè, Stefania Van Snick, Jacques Uyttenhove, Catherine Pilotte, Luc Van den Eynde, Benoît[UCL] (2021) Journal for immunotherapy of cancer — Vol. 9, no.2 (2021)

Journal article

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Klaessens, Simon[UCL] Stroobant, Vincent Hoffmann, Delia[UCL] Gyrd-Hansen, Mads Pilotte, Luc Vigneron, Nathalie[UCL] De Plaen, Etienne[UCL] Van den Eynde, Benoît[UCL] (2021) Proceedings of the National Academy of Sciences — Vol. 118, no.23, p. e2022447118 (2021)

Journal article

Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.

Schramme, Florence[UCL] Crosignani, Stefano Frederix, Kim[UCL] Hoffmann, Delia[UCL] Pilotte, Luc[UCL] Stroobant, Vincent[UCL] Preillon, Julie Driessens, Gregory[UCL] Van den Eynde, Benoît[UCL] (2020) Cancer immunology research — Vol. 8, no. 1, p. 32-45 (2020)

Journal article

Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase

Kozlova, Arina[UCL] Thabault, Léopold[UCL] Liberelle, Maxime[UCL] Klaessens, Simon[UCL] Prévost, Julien R. C.[UCL] Mathieu, Caroline[UCL] Pilotte, Luc[UCL] Stroobant, Vincent[UCL] Van den Eynde, Benoît[UCL] Frédérick, Raphaël[UCL] (2021) Journal of Medicinal Chemistry — (2021)

Journal article

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Solvay, Marie[UCL] Holfelder, Pauline Klaessens, Simon[UCL] Pilotte, Luc[UCL] Stroobant, Vincent[UCL] Lamy, Juliette Naulaerts, Stefan[UCL] Spillier, Quentin[UCL] Frédérick, Raphaël[UCL] De Plaen, Etienne[UCL] Sers, Christine Opitz, Christiane A Van den Eynde, Benoit[UCL] Zhu, Jingjing[UCL] (2023) Journal for ImmunoTherapy of Cancer — Vol. 11, no. 6, p. e006728 (2023)

Journal article

Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase

Kozlova, Arina[UCL] Thabault, Léopold[UCL] Dauguet, Nicolas[UCL] Deskeuvre, Marine[UCL] Stroobant, Vincent[UCL] Pilotte, Luc[UCL] Liberelle, Maxime[UCL] Van den Eynde, Benoit[UCL] Frédérick, Raphaël[UCL] (2022) European journal of medicinal chemistry — Vol. 227, p. 113892 [1-12] (2022)

Journal article

Minimal tolerance to a tumor antigen encoded by a cancer-germline gene

Huijbers, Ivo[UCL] Soudja, Saïdi M. Uyttenhove, Catherine[UCL] Buferne, Michel Inderberg-Suso, Else-Marit Colau, Didier[UCL] Pilotte, Luc[UCL] Powis de Tenbossche, Céline[UCL] Chomez, Patrick[UCL] Brasseur, Francis[UCL] Schmitt-Verhulst, Anne-Marie Van den Eynde, Benoît[UCL] (2012) Journal of Immunology — Vol. 188, no. 1, p. 111-121 (01/01/2012)

Journal article

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes

Orabona, Ciriana Mondanelli, Giada Pallotta, Maria T. Carvalho, Agostinho Albini, Elisa Fallarino, Francesca Vacca, Carmine Volpi, Claudia Belladonna, Maria L. Berioli, Maria G. Ceccarini, Giulia Esposito, Susanna M.R. Scattoni, Raffaella Verrotti, Alberto Ferretti, Alessandra De Giorgi, Giovanni Toni, Sonia Cappa, Marco Matteoli, Maria C. Bianchi, Roberta Matino, Davide Iacono, Alberta Puccetti, Matteo Cunha, Cristina Bicciato, Silvio Antognelli, Cinzia Talesa, Vincenzo N. Chatenoud, Lucienne Fuchs, Dietmar Pilotte, Luc Van den Eynde, Benoît[UCL] Lemos, Manuel C. Romani, Luigina Puccetti, Paolo Grohmann, Ursula (2018) JCI Insight — Vol. 3, no.6, p. e96244 (2018)

Journal article

Corrigendum to "Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors" (Bioorganic and Medicinal Chemistry (2011) (1550-1561))

Dolusic, Eduard[FUNDP] Larrieu, Pierre[UCL] Blanc, Sébastien Sapunaric, Frédéric Norberg, Bernadette[FUNDP] Moineaux, Laurence[FUNDP] Colette, Delphine Stroobant, Vincent[UCL] Pilotte, Luc[UCL] Colau, Didier[UCL] Ferain, Thierry Fraser, Graeme Galleni, Moreno Frre, Jean-Marie Masereel, Bernard[FUNDP] Van den Eynde, Benoît[UCL] Wouters, Johan[FUNDP] Frédérick, Raphaël[UCL] (2011) Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 19, no.9, p. 3029 (2011)

Journal article

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Dolusic, Eduard[FUNDP] Larrieu, Pierre[UCL] Moineaux, Laurence[FUNDP] Stroobant, Vincent[UCL] Pilotte, Luc[UCL] Colau, Didier[UCL] Pochet, Lionel[FUNDP] Van den Eynde, Benoît[UCL] Masereel, Bernard[FUNDP] Wouters, Johan[FUNDP] Frédérick, Raphaël[FUNDP] (2011) Journal of Medicinal Chemistry — Vol. 54, no. 15, p. 5320-5334 (11/08/2011)

Journal article

Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.

Dolusic, Eduard[FUNDP] Larrieu, Pierre[UCL] Meinguet, Céline[FUNDP] Colette, Delphine Rives, Arnaud Blanc, Sébastien Ferain, Thierry Pilotte, Luc[UCL] Stroobant, Vincent[UCL] Wouters, Johan[FUNDP] Van den Eynde, Benoît[UCL] Masereel, Bernard[FUNDP] Delfourne, Evelyne Frédérick, Raphaël[UCL] (2013) Bioorganic & Medicinal Chemistry Letters — Vol. 23, no.1, p. 47-54 (2013)

Journal article

Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells

Uzureau, Sophie Coquerelle, Caroline Vermeiren, Corentin Uzureau, Pierrick Van Acker, Annette Pilotte, Luc Monteyne, Daniel Acolty, Valérie Vanhollebeke, Benoit Van den Eynde, Benoît[UCL] Pérez-Morga, David Moser, Muriel Pays, Etienne (2016) European Journal of Immunology — Vol. 46, no.8, p. 1854-1866 (2016)

Journal article

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Röhrig, Ute F. Majjigapu, Somi Reddy Chambon, Marc Bron, Sylvian Pilotte, Luc[UCL] Colau, Didier[UCL] Van den Eynde, Benoît[UCL] Turcatti, Gerardo[UCL] Vogel, Pierre[UCL] Zoete, Vincent[UCL] Michielin, Olivier[UCL] (2014) European Journal of Medicinal Chemistry — Vol. 84, p. 284-301 (10/07/2014)

Journal article

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.

Röhrig, Ute F Majjigapu, Somi Reddy Grosdidier, Aurélien Bron, Sylvian Stroobant, Vincent Pilotte, Luc Colau, Didier Vogel, Pierre Van den Eynde, Benoît[UCL] Zoete, Vincent Michielin, Olivier (2012) Journal of Medicinal Chemistry — Vol. 55, no. 11, p. 5270-5290 (2012)

Journal article

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolusic, Eduard[FUNDP] Larrieu, Pierre[UCL] Blanc, Sébastien Sapunaric, Frédéric Norberg, Bernadette[FUNDP] Moineaux, Laurence[FUNDP] Colette, Delphine Stroobant, Vincent[UCL] Pilotte, Luc[UCL] Colau, Didier[UCL] Ferain, Thierry Fraser, Graeme Galleni, Moreno Frère, Jean-Marie Masereel, Bernard[FUNDP] Van den Eynde, Benoît[UCL] Wouters, Johan[FUNDP] Frédérick, Raphaël[UCL] (2011) Bioorganic & Medicinal Chemistry — Vol. 19, no. 4, p. 1550-1561 (2011)

Journal article

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase.

Pilotte, Luc Larrieu, Pierre Stroobant, Vincent Colau, Didier Dolusic, Eduard Frédérick, Raphaël De Plaen, Etienne Uyttenhove, Catherine Wouters, Johan Masereel, Bernard Van den Eynde, Benoît[UCL] (2012) Proceedings of the National Academy of Sciences of the United States of America — Vol. 109, no. 7, p. 2497-2502 (2012)

Journal article

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolusic, Eduard[FUNDP] Larrieu, Pierre[UCL] Blanc, Sébastien Sapunaric, Frédéric Pouyez, Jenny[FUNDP] Moineaux, Laurence[FUNDP] Colette, Delphine Stroobant, Vincent[UCL] Pilotte, Luc[UCL] Colau, Didier[UCL] Ferain, Thierry Fraser, Graeme Galleni, Moreno Frère, Jean-Marie Masereel, Bernard[FUNDP] Van den Eynde, Benoît[UCL] Wouters, Johan[FUNDP] Frédérick, Raphaël[UCL] (2011) European Journal of Medicinal Chemistry — Vol. 46, no. 7, p. 3058-3065 (2011)

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