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Determinants of serum levels of surfactant proteins A and B and Clara cell protein CC16.

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Hermans, Cédric [UCL] Dong, Ping Robin, Marjorie Jadoul, Michel [UCL] Bernard, Alfred [UCL] Doyle, Ian R

Increased leakage of surfactant proteins A and B (SP-A and SP-B) and Clara cell secretory protein (CC16) from the air spaces into the circulation occurs in a range of respiratory conditions. However, circulating levels depend not only on the rate of entry into the circulation, but also on the rate of clearance. In order to clarify the role of the kidney in the clearance of these proteins, serum levels were related to markers of glomerular filtration in 54 non-smoking patients with varying degrees of renal dysfunction, none of whom had respiratory disease or were receiving dialysis at the time of sampling. Serum SP-A was related to SP-B (r = 0.53, p < 0.001) and to CC16 (r = 0.33, p < 0.02). Similarly, SP-B was related to CC16 (r = 0.39, p < 0.004). Stepwise multiple linear regression analysis suggested that serum SP-A and SP-B are influenced by age (approximately 20 and approximately 25% of variance, respectively), whereas CC16 is determined by renal function and, to a lesser extent, by body weight (approximately 63% of variance in total). We conclude that CC16 is cleared from blood by the renal route, whereas SP-A and SP-B are not. Serum SP-A and SP-B are influenced by age, which we speculate reflects increased damage to the alveolocapillary barrier.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Journal information "Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals" - Vol. 8, no. 6, p. 461-471 (2003)
Peer reviewed yes
Publisher Taylor & Francis ((United Kingdom) London)
issn 1354-750X
e-issn 1366-5804
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/ESP - Ecole de santé publique
UCL - (SLuc) Service d'hématologie
UCL - (SLuc) Service de néphrologie
UCL - (SLuc) Centre de malformations vasculaires congénitales
MESH Subject Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Body Weight ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Diseases - blood ; Male ; Middle Aged ; Permeability ; Pulmonary Surfactant-Associated Protein A - blood ; Pulmonary Surfactant-Associated Protein B - blood ; Pulmonary Surfactant-Associated Proteins - blood ; Respiratory Distress Syndrome, Adult - blood ; Respiratory Mucosa - pathology ; Uteroglobin - blood
Links
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Bibliographic reference Hermans, Cédric ; Dong, Ping ; Robin, Marjorie ; Jadoul, Michel ; Bernard, Alfred ; et. al. Determinants of serum levels of surfactant proteins A and B and Clara cell protein CC16.. In: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 8, no. 6, p. 461-471 (2003)
Permanent URL http://hdl.handle.net/2078.1/9873