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Body structure versus body function in haemophilia : the case of haemophilic ankle arthropathy.

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Lobet, Sébastien [UCL] Hermans, Cédric [UCL] Pasta, Gianluigi Detrembleur, Christine [UCL]

Imaging and clinical scores are the main tools used to evaluate the progression of haemophilic arthropathy (HA). Based on haemophilic ankle arthropathy, this study aimed to explore the concordances between structural and clinical alterations, determined by standard radiological and clinical scores, and functional alterations assessed by three-dimensional gait analysis (3DGA). In total, 21 adult haemophilia patients underwent extensive ankle evaluation using the physical examination part of the World Federation of Haemophilia joint score, the Arnold-Hilgartner and the Pettersson radiological scores, and self-reported ankle function assessment using the revised Foot Function Index. Significant associations were found between self-reported ankle function assessment and the three 3DGA variables representative of joint function (range of motion, peak plantar flexion moment, and peak power generated at the push-off phase). Radiological and clinical scores were compared with ankle muscle peak power measurement, the most reliable 3DGA gait variable for ankle function. No significant associations were found between both clinical and functional scores and the 3DGA functional assessment. This discordance may be explained by the lack of a direct relationship between functional alterations detected by 3DGA and the structural changes assessed using X-ray or clinical scoring. Another explanation may be the limitation of clinical and radiological scoring systems in properly determining the severity of HA. Functional assessments such as 3DGA should be used more frequently when monitoring the progression of ankle arthropathy or the effects of therapeutic interventions in adult haemophilia patients.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Haemophilia : the official journal of the World Federation of Hemophilia" - Vol. 17, no. 3, p. 508-515 (2011)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. ((United Kingdom) Osney Mead, Oxford)
issn 1351-8216
e-issn 1365-2516
Publication status Publié
Affiliations UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
UCL - (SLuc) Service d'hématologie
UCL - (SLuc) Service de médecine physique et de réadaptation motrice
UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
MESH Subject Leg - physiopathology ; Male ; Middle Aged ; Muscle, Skeletal - physiopathology ; Paresis - physiopathology, rehabilitation ; Pilot Projects ; Time Factors ; Treatment Outcome ; Walking - physiology ; Adult ; Ankle Joint - physiopathology ; Young Adult ; Disability Evaluation ; Gait - physiology ; Hemophilia A - complications, physiopathology ; Humans ; Joint Diseases - physiopathology ; Middle Aged ; Psychometrics ; Range of Motion, Articular - physiology
Links
  1. World Health Organisation, International Classification of Functioning, Disability and Health (2001)
  2. SILVA M., LUCK J. V., QUON D., YOUNG C. R., CHIN D. M., EBRAMZADEH E., FONG Y.-J., Inter- and intra-observer reliability of radiographic scores commonly used for the evaluation of haemophilic arthropathy, 10.1111/j.1365-2516.2007.01630.x
  3. Barker Karen, Lamb Sarah E, Toye Francine, Jackson Sarah, Barrington Sharon, Association between radiographic joint space narrowing, function, pain and muscle power in severe osteoarthritis of the knee, 10.1191/0269215504cr754oa
  4. Szebenyi Béla, Hollander Anthony P., Dieppe Paul, Quilty Brian, Duddy John, Clarke Shane, Kirwan John R., Associations between pain, function, and radiographic features in osteoarthritis of the knee, 10.1002/art.21534
  5. Rodr??guez-Merch??n E. C., Effects of Hemophilia on Articulations of Children and Adults : , 10.1097/00003086-199607000-00003
  6. STEPHENSEN D., TAIT R. C., BRODIE N., COLLINS P., CHEAL R., KEELING D., MELTON K., DOLAN G., HAYE H., HAYMAN E., WINTER M., Changing patterns of bleeding in patients with severe haemophilia A, 10.1111/j.1365-2516.2008.01876.x
  7. Gilbert, Semin Hematol, 30, 3 (1993)
  8. Greene W B, Yankaskas B C, Guilford W B, Roentgenographic classifications of hemophilic arthropathy. Comparison of three systems and correlation with clinical parameters. : , 10.2106/00004623-198971020-00010
  9. Arnold WD, Hilgartner MW, Hemophilic arthropathy. Current concepts of pathogenesis and management : , 10.2106/00004623-197759030-00001
  10. Pettersson, Clin Orthop Relat Res, Jun, 153 (1980)
  11. Budiman-Mak Elly, Conrad Kendon, Stuck Rodney, Matters Michael, Theoretical Model and Rasch Analysis to Develop a Revised Foot Function Index, 10.1177/107110070602700707
  12. LOBET S., DETREMBLEUR C., FRANCQ B., HERMANS C., Natural progression of blood-induced joint damage in patients with haemophilia: clinical relevance and reproducibility of three-dimensional gait analysis : NATURAL PROGRESSION OF HAEMOPHILIC ARTHROPATHY, 10.1111/j.1365-2516.2010.02245.x
  13. Dierick Frédéric, Penta Massimo, Renaut David, Detrembleur Christine, A force measuring treadmill in clinical gait analysis, 10.1016/j.gaitpost.2003.11.001
  14. Chester, Biomed Instrum Technol, 39, 64 (2005)
  15. Chen Shing-Jye, Pipinos Iraklis, Johanning Jason, Radovic Matija, Huisinga Jessie M., Myers Sara A., Stergiou Nick, Bilateral claudication results in alterations in the gait biomechanics at the hip and ankle joints, 10.1016/j.jbiomech.2008.05.011
  16. Dogan S., Manley P.A., Vanderby R., Kohles S.S., Hartman L.M., McBeath A.A., Canine intersegmental hip joint forces and moments before and after cemented total hip replacement, 10.1016/0021-9290(91)90028-l
  17. Stoquart G., Detrembleur C., Lejeune T., Effect of speed on kinematic, kinetic, electromyographic and energetic reference values during treadmill walking, 10.1016/j.neucli.2008.02.002
  18. Detrembleur C., Leemrijse T., The effects of total ankle replacement on gait disability: Analysis of energetic and mechanical variables, 10.1016/j.gaitpost.2008.09.009
  19. Manco-Johnson M. J., Pettersson H., Petrini P., Babyn P. S., Bergstrom B-M., Bradley C.-S., Doria A. S., Feldman B. M., Funk S., Hilliard P., Kilcoyne R., Lundin B., Nuss R., Rivard G., Schoenmakers M. A. G. C., Van den berg M., Wiedel J., Zourikian N., Blanchette V. S., Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions, 10.1111/j.1365-2516.2004.00978.x
  20. Wallny T., Lahaye L., Brackmann H. H., Hess L., Seuser A, Kraft C. N., Clinical and radiographic scores in haemophilic arthropathies: how well do these correlate to subjective pain status and daily activities?, 10.1046/j.1365-2516.2002.00680.x
  21. Hamel J., Pohlmann H., Schramm W., Radiological evaluation of chronic hemophilic arthropathy by the Pettersson score: problems in correlation in adult patients, 10.1007/bf00361453
  22. PERGANTOU H., MATSINOS G., PAPADOPOULOS A., PLATOKOUKI H., ARONIS S., Comparative study of validity of clinical, X-ray and magnetic resonance imaging scores in evaluation and management of haemophilic arthropathy in children, 10.1111/j.1365-2516.2006.01208.x
  23. Solovieva S., Clinical severity of disease, functional disability and health-related quality of life. Three-year follow-up study of 150 Finnish patients with coagulation disorders, 10.1046/j.1365-2516.2001.00476.x
  24. GENDEREN F. R., FISCHER K., HEIJNEN L., KLEIJN P., BERG H. M., HELDERS P. J. M., MEETEREN N. L. U., Pain and functional limitations in patients with severe haemophilia, 10.1111/j.1365-2516.2006.01203.x
  25. Hadler Nortin M., Knee Pain Is the Malady—Not Osteoarthritis, 10.7326/0003-4819-116-7-598
  26. Klukowska A., Czyrny Z., Laguna P., Brzewski M., Serafin-Krol M. A., Rokicka-Milewska R., Correlation between clinical, radiological and ultrasonographical image of knee joints in children with haemophilia, 10.1046/j.1365-2516.2001.00509.x
  27. Pergantou Helen, Matsinos George, Platokouki Helen, Papadopoulos Andreas, Aronis Sophie, An attempt to improve the clinical scale for assessment of haemophilic arthropathy in children : , 10.1097/bpb.0b013e32832bf5ad
  28. YU W., LIN Q., GUERMAZI A., YU X., SHANG W., ZHU H., MENG W., XU R., ZHAO Y., Comparison of radiography, CT and MR imaging in detection of arthropathies in patients with haemophilia, 10.1111/j.1365-2516.2009.02044.x
  29. Ng W. H., Chu W. C. W., Shing M. K., Lam W. W. M., Chik K. W., Li C. K., Li C. K., Ling S. C., Role of Imaging in Management of Hemophilic Patients, 10.2214/ajr.184.5.01841619
  30. Jelbert A., Vaidya S., Fotiadis N., Imaging and staging of haemophilic arthropathy, 10.1016/j.crad.2009.07.005
  31. De Kleijn P., Heijnen L., Van Meeteren N. L. U., Clinimetric instruments to assess functional health status in patients with haemophilia: a literature review, 10.1046/j.1365-2516.2002.00640.x
  32. Detrembleur C., De Nayer J., van den Hecke A., Celecoxib improves the efficiency of the locomotor mechanism in patients with knee osteoarthritis. A randomised, placebo, double-blind and cross-over trial, 10.1016/j.joca.2004.11.002
  33. Aznar J. A., Magallon M., Querol F., Gorina E., Tusell J. M., The orthopaedic status of severe haemophiliacs in Spain, 10.1046/j.1365-2516.2000.00397.x
  34. HILLIARD P., FUNK S., ZOURIKIAN N., BERGSTROM B.-M., BRADLEY C. S., MCLIMONT M., MANCO-JOHNSON M., PETRINI P., VAN DEN BERG M., FELDMAN B. M., Hemophilia joint health score reliability study, 10.1111/j.1365-2516.2006.01312.x
  35. GENDEREN F. R., WESTERS P., HEIJNEN L., KLEIJN P., BERG H. M., HELDERS P. J. M., MEETEREN N. L. U., Measuring patients' perceptions on their functional abilities: validation of the Haemophilia Activities List, 10.1111/j.1365-2516.2006.01186.x
  36. Poonnoose P. M., Manigandan C., Thomas R., Shyamkumar N. K., Kavitha M. L., Bhattacharji S., Srivastava A., Functional Independence Score in Haemophilia: a new performance-based instrument to measure disability, 10.1111/j.1365-2516.2005.01142.x
  37. POONNOOSE P. M., THOMAS R., KESHAVA S. N., CHERIAN R. S., PADANKATTI S., PAZANI D., KAVITHA M. L., DEVADARASINI M., BHATTACHARJI S., VISWABANDYA A., JOHN J. A., MACADEN A. S., MATHEWS V., SRIVASTAVA A., Psychometric analysis of the Functional Independence Score in Haemophilia (FISH), 10.1111/j.1365-2516.2007.01508.x
  38. BEETON K., DE KLEIJN P., HILLIARD P., FUNK S., ZOURIKIAN N., BERGSTROM B.-M., ENGELBERT R. H. H., VAN DER NET J. J., MANCO-JOHNSON M. J., PETRINI P., VAN DEN BERG M., ABAD A., FELDMAN B. M., DORIA A. S., LUNDIN B., POONNOOSE P. M., JOHN J. A., KAVITHA M. L., PADANKATTI S. M., DEVADARASINI M., PAZANI D., SRIVASTAVA A., VAN GENDEREN F. R., VACHALATHITI R., Recent developments in clinimetric instruments, 10.1111/j.1365-2516.2006.01265.x
Bibliographic reference Lobet, Sébastien ; Hermans, Cédric ; Pasta, Gianluigi ; Detrembleur, Christine. Body structure versus body function in haemophilia : the case of haemophilic ankle arthropathy.. In: Haemophilia : the official journal of the World Federation of Hemophilia, Vol. 17, no. 3, p. 508-515 (2011)
Permanent URL http://hdl.handle.net/2078.1/96092