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Impact of freezing and thawing of human ovarian tissue on follicular growth after long-term xenotransplantation.

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Andrade Amorim, Christiani [UCL] David, Anu [UCL] Dolmans, Marie-Madeleine [UCL] Camboni, Alessandra [UCL] Donnez, Jacques [UCL] Van Langendonckt, Anne [UCL]

PURPOSE: To assess follicular growth after xenografting in order to understand how freezing and/or grafting may affect follicular development. METHODS: Human ovarian biopsies were used for fresh and frozen-thawed xenografting to SCID mice. After xenotransplantation, follicular morphology and proportion, oocyte and follicle diameter, and quantitative and qualitative parameters of antral follicles were analyzed. RESULTS: The proportion of growing follicles was significantly higher in grafted than non-grafted ovarian tissue. Follicular growth to the antral stage was observed and there was no significant difference in oocyte or follicle diameter in fresh or frozen-thawed grafts. Although no significant difference was observed in antral area or zona pellucida thickness, the theca layer in antral follicles from frozen-thawed grafted tissue was found to be significantly thinner than in fresh grafts. CONCLUSION: Antral follicles obtained after grafting of frozen-thawed human ovarian tissue showed a thinner theca cell layer compared to those from fresh grafts, which could affect follicular development and function. Further studies are nevertheless warranted to confirm the identity of theca cells and assess if they retain the ability to respond to luteinizing hormone and produce androgens.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "Journal of Assisted Reproduction and Genetics" - Vol. 28, no. 12, p. 1157-1165 (2011)
Peer reviewed yes
Publisher Springer New York LLC ((United States) New York)
issn 1058-0468
e-issn 1573-7330
Publication status Publié
Affiliations UCL - SSS/IREC/GYNE - Pôle de Gynécologie
UCL - (SLuc) Service de gynécologie et d'andrologie
Keywords Ovarian tissue ; Follicles ; Xenotransplantation ; Cryopreservation ; Theca cell alyer
Links
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Bibliographic reference Andrade Amorim, Christiani ; David, Anu ; Dolmans, Marie-Madeleine ; Camboni, Alessandra ; Donnez, Jacques ; et. al. Impact of freezing and thawing of human ovarian tissue on follicular growth after long-term xenotransplantation.. In: Journal of Assisted Reproduction and Genetics, Vol. 28, no. 12, p. 1157-1165 (2011)
Permanent URL http://hdl.handle.net/2078.1/95364