Markine-Goriaynoff, Dominique
[UCL]
Hulhoven, Xavier
[UCL]
Cambiaso, Cesar
[UCL]
Monteyne, Philippe
[UCL]
Briet, Thérèse
[UCL]
Gonzalez, Maria-Dolores
[UCL]
Coulie, Pierre G.
[UCL]
Coutelier, Jean-Paul
[UCL]
Early after infection, lactate dehydrogenase-elevating virus (LDV) alters the immune system by polyclonally activating B lymphocytes, which leads to IgG2a-restricted hypergammaglobulinaemia, and by suppressing the secretion of Th2 cytokines. Considering that these alterations may involve cells of the innate immune system and cytokines such as interferon-gamma (IFN-gamma), we analysed the effect of LDV on natural killer (NK) cells. Within a few days of infection, a strong and transient NK cell activation, characterized by enhanced IFN-gamma message expression and cytolysis, was observed. LDV triggered a large increase in serum IFN-gamma levels. Because NK cells and IFN-gamma may participate in the defence against virus infection, we analysed their possible role in the control of LDV titres with a new agglutination assay. Our results indicate that neither the activation of NK cells nor the IFN-gamma secretion affect the early and rapid virus replication that follows LDV inoculation.
Bibliographic reference |
Markine-Goriaynoff, Dominique ; Hulhoven, Xavier ; Cambiaso, Cesar ; Monteyne, Philippe ; Briet, Thérèse ; et. al. Natural killer cell activation after infection with lactate dehydrogenase-elevating virus.. In: Journal of General Virology, Vol. 83, no. Pt 11, p. 2709-2716 (2002) |
Permanent URL |
http://hdl.handle.net/2078.1/9276 |