User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Botulinum toxin and short-term electrical stimulation in the treatment of equinus in cerebral palsy

Primary tabs

Detrembleur, Christine [UCL] Lejeune, Thierry [UCL] Renders, Anne [UCL] Van den Bergh, Peter [UCL]

Intramuscular botulinum toxin type A (BT-A) has been shown to reduce spasticity and to improve gait in children with cerebral palsy. To determine whether the efficacy of BT-A may be enhanced by electrical stimulation, as suggested in focal dystonia or in adult spastic patients, 12 children with dynamic foot equinus deformity were randomly assigned to two groups in a blinded, clinically controlled trial. Intramuscular BT-A into calf muscles was followed by adjuvant electrical stimulation in Group A (n = 6) but not in Group B (n = 6). Clinical assessment and instrumented gait analysis were performed before and 1, 3, and 6 months after treatment. The combined treatment of BT-A and electrical stimulation was not superior to BT-A alone. For all patients, improvement of the clinical and gait variables occurred at 1 and 3 months after BT-A injection.

Document type Article de périodique (Journal article) – Article de recherche – Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2001
Language Anglais
Journal information "Movement Disorders" - Vol. 17, no. 1, p. 162-169 (2002)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. (Hoboken)
issn 0885-3185
e-issn 1531-8257
Publication status Publié
Affiliations UCL - MD/IEPR - Institut d'éducation physique et de réadaptation
UCL - MD/NOPS - Département de neurologie et de psychiatrie
UCL - (SLuc) Service de neurologie
UCL - (SLuc) Centre de référence en infirmité motrice cérébrale
UCL - (SLuc) Service de médecine physique et de réadaptation motrice
MESH Subject Botulinum Toxin Type A - administration & dosage - therapeutic use ; Cerebral Palsy - complications ; Child ; Child, Preschool ; Electric Stimulation Therapy - methods ; Electromyography ; Equinus Deformity - complications - drug therapy - therapy ; Female ; Gait ; Humans ; Male ; Neuromuscular Agents - administration & dosage - therapeutic use ; Random Allocation ; Severity of Illness Index
Keywords Cerebral palsy ; Foot equinus ; Botulinum toxin type A ; Gait analysis ; Electrical stimulation
Links
  1. Gage, Gait analysis in cerebral palsy (1991)
  2. Cosgrove A. P., Graham H. K., BOTUNUM TOXIN A PREVENTS THE DEVELOPMENT OF CONTRACTURES IN THE HEREDITARY SPASTC MOUSE, 10.1111/j.1469-8749.1994.tb11863.x
  3. Forssberg Hans, Tedroff Kristina B., Botulinum toxin treatment in cerebral palsy: intervention with poor evaluation?, 10.1111/j.1469-8749.1997.tb07501.x
  4. Koman L Andrew, Mooney James F., Smith Beth P., Goodman Amy, Mulvaney Theresa, Management of Spasticity in Cerebral Palsy with Botulinum-A Toxin: Report of a Preliminary, Randomized, Double-Blind Trial : , 10.1097/01241398-199405000-00005
  5. Corry I. S., Cosgrove A. P., Duffy C. M., McNeill S., Taylor T. C., Graham H. K., Botulinum Toxin A Compared with Stretching Casts in the Treatment of Spastic Equinus: A Randomised Prospective Trial : , 10.1097/01241398-199805000-00006
  6. Sutherland David H, Kaufman Kenton R, Wyatt Marilynn P, Chambers Henry G, Mubarak Scott J, Double-blind study of botulinum A toxin injections into the gastrocnemius muscle in patients with cerebral palsy, 10.1016/s0966-6362(99)00012-0
  7. Koman L. Andrew, Mooney James F., Smith Beth Paterson, Walker Francis, Leon Judith M., Botulinum Toxin Type A Neuromuscular Blockade in the Treatment of Lower Extremity Spasticity in Cerebral Palsy: A Randomized, Double-Blind, Placebo-Controlled Trial : , 10.1097/01241398-200001000-00022
  8. Cosgrove A. P., Corry I. S., Graham H. K., BOTULINUM TOXIN IN THE MANAGEMENT OF THE LOWER LIMB IN CEREBRAL PALSY, 10.1111/j.1469-8749.1994.tb11864.x
  9. Sutherland David H., Kaufman Kenton R., Wyatt Marilynn P., Chambers Henry G., Injection of botulinum A toxin into the gastrocnemius muscle of patients with cerebral palsy: a 3-dimensional motion analysis study, 10.1016/0966-6362(95)01054-8
  10. Boyd Roslyn N, Pliatsios Victoria, Starr Roland, Wolfe Rory, Graham H Kerr, Biomechanical transformation of the gastroc–soleus muscle with botulinum toxin A in children with cerebral palsy, 10.1017/s0012162200000074
  11. Eleopra R., Tugnoli V., de Grandis D., The variability in the clinical effect induced by botulinum toxin type A: The role of muscle activity in humans, 10.1002/mds.870120115
  12. Hughes R., Whaler B. C., Influence of nerve-ending activity and of drugs on the rate of paralysis of rat diaphragm preparation byCl. botulinumtype A toxin, 10.1113/jphysiol.1962.sp006843
  13. Crenna P., Inverno M., Frigo C., Palmieri R., Fedrizzi E., Pathophysiological Profile of Gait in Children with Cerebral Palsy, Movement Disorders in Children ISBN:9783805555562 p.186-198, 10.1159/000421492
  14. Berger W, Horstmann G, Dietz V, Tension development and muscle activation in the leg during gait in spastic hemiparesis: independence of muscle hypertonia and exaggerated stretch reflexes., 10.1136/jnnp.47.9.1029
  15. Hesse S., Jahnke M.T., Luecke D., Mauritz K.H., Short-term electrical stimulation enhances the effectiveness of Botulinum toxin in the treatment of lower limb spasticity in hemiparetic patients, 10.1016/0304-3940(94)12124-9
  16. Hesse Stefan, Reiter Frank, Konrad Matthias, Jahnke Matthias T, Botulinum toxin type A and short-term electrical stimulation in the treatment of upper limb flexor spasticity after stroke: a randomized, double-blind, placebo-controlled trial, 10.1191/026921598668275996
  17. Bohannon Richard W., Smith Melissa B., Interrater Reliability of a Modified Ashworth Scale of Muscle Spasticity, 10.1093/ptj/67.2.206
  18. Bates, A guide to physical examination and history taking (1991)
  19. Cavagna, J Appl Physiol, 39, 174 (1975)
  20. Yang Jaynie F., Stephens Marilee J., Vishram Rosie, Infant stepping: a method to study the sensory control of human walking, 10.1111/j.1469-7793.1998.927bs.x
  21. Detrembleur Christine, Plaghki Léon, Quantitative assessment of intrathecally administered baclofen in spasticity, 10.1016/s0003-9993(00)90071-6
  22. Bronfenbrenner J. J., THE EFFECT OF ANESTHESIA AND OF SEDATIVES ON THE SERUM THERAPY OF EXPERIMENTAL BOTULISM, 10.1084/jem.39.4.517
  23. Simpson, J Pharmacol Exp Ther, 212, 16 (1980)
  24. Cavagna Giovanni A., STORAGE AND UTILIZATION OF ELASTIC ENERGY IN SKELETAL MUSCLE : , 10.1249/00003677-197700050-00004
  25. Massin Martial, Allington Nanni, Role of Exercise Testing in the Functional Assessment of Cerebral Palsy Children After Botulinum A Toxin Injection : , 10.1097/01241398-199905000-00015
  26. Forssberg, Neurophysiology and neuropsychology of motor development, 78 (1997)
  27. Leonard Charles T., Moritani Toshio, Hirschfeld Helga, Forssberg Hans, DEFICITS IN RECIPROCAL INHIBITION OF CHILDREN WITH CEREBRAL PALSY AS REVEALED BY H REFLEX TESTING, 10.1111/j.1469-8749.1990.tb08120.x
  28. Rosales Raymond L., Arimura Kimiyoshi, Takenaga Satoshi, Osame Mitsuhiro, Extrafusal and intrafusal muscle effects in experimental botulinum toxin-A injection, 10.1002/(sici)1097-4598(199604)19:4<488::aid-mus9>3.0.co;2-8
  29. Wiegand H., Wellh�ner H. H., The action of botulinum A neurotoxin on the inhibition by antidromic stimulation of the lumbar monosynaptic reflex, 10.1007/bf00500893
  30. Priori Alberto, Berardelli Alfredo, Mercuri Bruno, Manfredi Mario, Physiological effects produced by botulinum toxin: Changes in reciprocal inhibition between forearm muscles, 10.1093/brain/118.3.801
  31. Girlanda Paolo, Quartarone Angelo, Sinicropi Stefano, Nicolosi Carmelo, Roberto Maria Luisa, Picciolo Giuseppe, Macaione Vincenzo, Battaglia Fortunato, Ruggeri Maria, Messina Corrado, Botulinum toxin in upper limb spasticity : study of reciprocal inhibition between forearm muscles, 10.1097/00001756-199709290-00008
Bibliographic reference Detrembleur, Christine ; Lejeune, Thierry ; Renders, Anne ; Van den Bergh, Peter. Botulinum toxin and short-term electrical stimulation in the treatment of equinus in cerebral palsy. In: Movement Disorders, Vol. 17, no. 1, p. 162-169 (2002)
Permanent URL http://hdl.handle.net/2078.1/9066