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Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants.

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Markine-Goriaynoff, Dominique [UCL] Coutelier, Jean-Paul [UCL]

Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did the other subclasses. This suggests that the IgG2a predominance observed in many IgG antibody responses elicited by live viruses could, at least under some circumstances, correspond to the selection of the best protection for the infected host.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2002
Journal information "Journal of virology" - Vol. 76, no. 1, p. 432-5 (2002)
Peer reviewed yes
issn 0022-538X
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Antibodies, Monoclonal - genetics - therapeutic use ; Antibodies, Viral - genetics - therapeutic use ; Encephalomyelitis - therapy - virology ; Female ; Immunocompromised Host ; Immunoglobulin G - genetics - therapeutic use ; Lactate dehydrogenase-elevating virus - immunology ; Mice ; Somatic Hypermutation, Immunoglobulin
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Bibliographic reference Markine-Goriaynoff, Dominique ; Coutelier, Jean-Paul. Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants.. In: Journal of virology, Vol. 76, no. 1, p. 432-5 (2002)
Permanent URL http://hdl.handle.net/2078.1/9011