User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic ethanol administration.

Primary tabs

Lallemand, Frédéric [UCL] Soubrié, P H De Witte, Philippe [UCL]

BACKGROUND: Chronic ethanol administration results in neurobiological alterations similar to those observed after chronic cannabinoid exposure. The purpose of this study was to investigate alcohol drinking and the withdrawal responses after pulmonary chronic alcoholization with intraperitoneal or oral administration of a cannabinoid CB1 receptor antagonist. METHODS: The cannabinoid receptor antagonist SR141716A, 1, 3 or 10 mg/kg/day intraperitoneally or orally, was administered to Wistar rats either during a 30-day chronic ethanol exposure or at the cessation of this procedure. Motility was recorded during 18 hr after the cessation of chronic alcoholization just before the beginning of the free-choice paradigm (water versus alcohol 10% v/v). RESULTS: A significant increase in ethanol preference was observed during the free-choice paradigm after chronic alcoholization with concurrent SR141716A administration (3 or 10 mg/kg/day). A significant decrease in withdrawal motility after administration of SR141716A was observed with only the highest dose (10 mg/kg/day). The administration of SR141716A, 3 or 10 mg/kg/day, after chronic pulmonary alcoholization significantly decreased the preference for alcohol. Finally, a significant decrease in ethanol preference was seen during the free-choice paradigm of nonalcoholized rats treated with SR141716A, 3 or 10 mg/kg/day, during 30 days before the free-choice paradigm. CONCLUSIONS: The concurrent administration of the CB1 antagonist together with the chronic alcoholization increases the preference for ethanol. Also, the administration of the CB1 antagonist after the chronic alcoholization or at the time of withdrawal drastically diminishes the ethanol preference.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 2001
Journal information "Alcoholism, clinical and experimental research" - Vol. 25, no. 9, p. 1317-23 (2001)
Peer reviewed yes
issn 0145-6008
Publication status Publié
Affiliation UCL
MESH Subject Animals ; Body Weight ; Drinking ; Ethanol - administration & dosage - blood ; Kinetics ; Male ; Motor Activity ; Piperidines - administration & dosage - pharmacology ; Pyrazoles - administration & dosage - pharmacology ; Rats ; Rats, Wistar ; Receptors, Cannabinoid ; Receptors, Drug - antagonists & inhibitors ; Self Administration
Links
  1. Ameri Angela, The effects of cannabinoids on the brain, 10.1016/s0301-0082(98)00087-2
  2. Arnone Michèle, Maruani Jeanne, Chaperon Frédérique, Thiébot Marie-Hélène, Poncelet M., Soubrié Philippe, Fur Gérard Le, Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors, 10.1007/s002130050326
  3. Basavarajappa Balapal S., Cooper Thomas B., Hungund Basalingappa L., Chronic ethanol administration down-regulates cannabinoid receptors in mouse brain synaptic plasma membrane, 10.1016/s0006-8993(98)00175-9
  4. Basavarajappa Balapal S, Hungund Basalingappa L, Chronic Ethanol Increases the Cannabinoid Receptor Agonist Anandamide and Its Precursor N-Arachidonoylphosphatidylethanolamine in SK - N - SH Cells, 10.1046/j.1471-4159.1999.0720522.x
  5. Basavarajappa BS, Alcohol Clin Exp Res, 21, 1199 (1997)
  6. Charlton ME, J Neurochem, 68, 121 (1997)
  7. COLOMBO G., AGABIO R., FA M., GUANO L., LOCHE A., REALI R., GESSA G. L., REDUCTION OF VOLUNTARY ETHANOL INTAKE IN ETHANOL-PREFERRING sP RATS BY THE CANNABINOID ANTAGONIST SR-141716, 10.1093/oxfordjournals.alcalc.a008368
  8. Dahchour Abdelkader, De Witte Philippe, Acamprosate Decreases the Hypermotility During Repeated Ethanol Withdrawal, 10.1016/s0741-8329(98)00071-8
  9. Devaud LL, J Neurochem, 69, 126 (1997)
  10. Fadda F, Chronic ethanol consumption:from neuroadaptation to neurodegeneration, 10.1016/s0301-0082(98)00032-x
  11. Faingold C.L, N'Gouemo P, Riaz A, Ethanol and neurotransmitter interactions—from molecular to integrative effects, 10.1016/s0301-0082(98)00027-6
  12. Gallate Jason E., McGregor I. S., The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716, 10.1007/s002130050893
  13. Gallate Jason E., Saharov Tanya, Mallet Paul E., McGregor Iain S., Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist, 10.1016/s0014-2999(99)00170-3
  14. Gardner Eliot L., Vorel S.Robert, Cannabinoid Transmission and Reward-Related Events, 10.1006/nbdi.1998.0219
  15. Kandel ER, Principles of Neural Science (1991)
  16. Bourhis B, C R Seances Soc Biol Fil, 169, 898 (1975)
  17. LEBOURHIS B, Sur l'etablissement de la dependance des rats a l'egard de l'alcool, 10.1016/0031-9384(77)90261-x
  18. Levenes C, J Physiol, 510, 867 (1998)
  19. Lovinger David M., Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells, 10.1016/0304-3940(91)90192-v
  20. Maneuf Yannick P., Nash Joanne E., Crossman Alan R., Brotchie Jonathan M., Activation of the cannabinoid receptor by Δ9-tetrahydrocannabinol reduces γ-aminobutyric acid uptake in the globus pallidus, 10.1016/0014-2999(96)00326-3
  21. Meert TF, Behav Pharmacol, 3, 601 (1992)
  22. Montpied P, Mol Pharmacol, 39, 157 (1991)
  23. Navarro M, Neuroreport, 9, 3397 (1998)
  24. Rinaldi-Carmona Murielle, Barth Francis, Héaulme Michel, Shire David, Calandra Bernard, Congy Christian, Martinez Serge, Maruani Jeanne, Néliat Gervais, Caput Daniel, Ferrara Pascual, Soubrié Philippe, Brelière Jean Claude, Le Fur Gérard, SR141716A, a potent and selective antagonist of the brain cannabinoid receptor, 10.1016/0014-5793(94)00773-x
  25. Rodriguez de Fonseca F, Ann Med, 30, 397 (1998)
  26. Rodriguez de Fonseca F, Zhongguo Yao Li Xue Bao, 20, 1109 (1999)
  27. Romero J, de Miguel R, Ramos J.A, Fernández-Ruiz J.J, THE ACTIVATION OF CANNABINOID RECEPTORS IN STRIATONIGRAL GABAERGIC NEURONS INHIBITED GABA UPTAKE, 10.1016/s0024-3205(97)01117-x
  28. Sañudo-Peña M.Clara, Tsou Kang, Delay Eugene R, Hohman Andrea G, Force Michelle, Walker J.Michael, Endogenous cannabinoids as an aversive or counter-rewarding system in the rat, 10.1016/s0304-3940(97)13424-3
  29. Shimizu K, Matsubara K, Uezono T, Kimura K, Shiono H, Reduced dorsal hippocampal glutamate release significantly correlates with the spatial memory deficits produced by benzodiazepines and ethanol, 10.1016/s0306-4522(97)00339-4
  30. Tsou K, Brown S, Sañudo-Peña M.C, Mackie K, Walker J.M, Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system, 10.1016/s0306-4522(97)00436-3
Bibliographic reference Lallemand, Frédéric ; Soubrié, P H ; De Witte, Philippe. Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic ethanol administration.. In: Alcoholism, clinical and experimental research, Vol. 25, no. 9, p. 1317-23 (2001)
Permanent URL http://hdl.handle.net/2078.1/8956