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Development of a pyrosequencing assay for rapid assessment of quinolone resistance in Acinetobacter baumannii isolates.

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Deccache, Yann [UCL] Irenge, Léonid M [UCL] Savov, Encho Ariciuc, Mihaela Macovei, Alexandra Ambroise, Jérôme [UCL] Gala, Jean-Luc [UCL]

Rapid and reliable assessment of Acinetobacter baumannii resistance to quinolones was successfully achieved through pyrosequencing of the gyrA and parC quinolone-resistance determining regions. A strong correlation was found between quinolone resistance and mutations in gyrA codon 83 and/or in the parC gene (codons 80 or 84). Absence of QRDR mutations was associated with susceptibility to quinolones.

Bibliographic reference Deccache, Yann ; Irenge, Léonid M ; Savov, Encho ; Ariciuc, Mihaela ; Macovei, Alexandra ; et. al. Development of a pyrosequencing assay for rapid assessment of quinolone resistance in Acinetobacter baumannii isolates.. In: Journal of Microbiological Methods, Vol. 86, no. 1, p. 115-118 (2011)
Permanent URL http://hdl.handle.net/2078.1/88561