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Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.

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Dumoutier, Laure [UCL] Van Roost, Emiel [UCL] Colau, Didier [UCL] Renauld, Jean-Christophe [UCL]

IL-10-related T cell-derived inducible factor (IL-TIF or IL-21) is a new cytokine structurally related to IL-10 and originally identified in the mouse as a gene induced by IL-9 in T cells and mast cells. Here, we report the cloning of the human IL-TIF cDNA, which shares 79% amino acid identity with mouse IL-TIF and 25% identity with human IL-10. Recombinant human IL-TIF was found to activate signal transducer and activator of transcription factors-1 and -3 in several hepatoma cell lines. IL-TIF stimulation of HepG2 human hepatoma cells up-regulated the production of acute phase reactants such as serum amyloid A, alpha1-antichymotrypsin, and haptoglobin. Although IL-10 and IL-TIF have distinct activities, antibodies directed against the beta chain of the IL-10 receptor blocked the induction of acute phase reactants by IL-TIF, indicating that this chain is a common component of the IL-10 and IL-TIF receptors. Similar acute phase reactant induction was observed in mouse liver upon IL-TIF injection, and IL-TIF expression was found to be rapidly increased after lipopolysaccharide (LPS) injection, suggesting that this cytokine contributes to the inflammatory response in vivo.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2000
Journal information "Proceedings of the National Academy of Sciences of the United States of America" - Vol. 97, no. 18, p. 10144-9 (2000)
Peer reviewed yes
issn 0027-8424
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Acute-Phase Proteins - genetics ; Amino Acid Sequence ; Animals ; Carcinoma, Hepatocellular ; Cell Line ; Cells, Cultured ; Cloning, Molecular ; Cytokines - chemistry - genetics - pharmacology - physiology ; DNA, Complementary ; Escherichia coli ; Female ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Interleukin-10 - immunology ; Liver Neoplasms ; Mice ; Mice, Inbred C3H ; Molecular Sequence Data ; Recombinant Proteins - chemistry - pharmacology ; Sequence Alignment ; Sequence Homology, Amino Acid ; Signal Transduction ; T-Lymphocytes - immunology ; Trans-Activators - metabolism ; Tumor Cells, Cultured
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Bibliographic reference Dumoutier, Laure ; Van Roost, Emiel ; Colau, Didier ; Renauld, Jean-Christophe. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, no. 18, p. 10144-9 (2000)
Permanent URL http://hdl.handle.net/2078.1/8614