Heidecker, Leonora
[UCL]
Brasseur, Francis
[UCL]
Probst-Kepper, Michael
[UCL]
Guéguen, Maryse
[UCL]
Boon, Thierry
[UCL]
Van den Eynde, Benoît
[UCL]
Human bladder carcinoma line LB831-BLC expresses several distinct Ags that are recognized by different autologous CTL. Here, we show that one of these Ags is presented by HLA-Cw7 and encoded by gene MAGE-A12. This is the first time that CTL directed against a MAGE-encoded Ag have been derived from the lymphocytes of a patient with cancer other than melanoma. This new Ag was found to be nonapeptide VRIGHLYIL, corresponding to position 170-178 of the MAGE-A12 protein. Gene MAGE-A12 is silent in normal tissues except in male germline cells, which do not express HLA molecules. It is expressed in 26-62% of melanomas, infiltrating bladder carcinomas, lung carcinomas, esophageal carcinomas, and head and neck carcinomas. Because HLA-Cw7 is present in 43% of Caucasians, this new Ag is shared by many tumors and should be a useful target for cancer immunotherapy.
Bibliographic reference |
Heidecker, Leonora ; Brasseur, Francis ; Probst-Kepper, Michael ; Guéguen, Maryse ; Boon, Thierry ; et. al. Cytolytic T lymphocytes raised against a human bladder carcinoma recognize an antigen encoded by gene MAGE-A12.. In: Journal of Immunology, Vol. 164, no. 11, p. 6041-6045 (2000) |
Permanent URL |
http://hdl.handle.net/2078.1/8522 |