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Evidence for a neuroprotective effect of pyrid-3-yl-sulphonyl-urea in photochemically induced focal ischaemia in rats: magnetic resonance imaging evaluation.

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Baudelet, Christine [UCL] Demeure, R. Frois, A Masereel, Bernard [FUNDP] Goudemant, Jean-François [UCL] Ritter, Christian [UCL] Gallez, Bernard [UCL]

A neuroprotective effect can be obtained with N-[(4-cycloheptylaminopyrid-3-yl)sulphonyl]N'-cycloheptyl urea (BM27), a pyrid-3-yl-sulphonylurea structurally related to torasemide, a loop diuretic. We have investigated the neuroprotective effect of BM27 by magnetic resonance imaging and use of the photothrombotic model of cerebral infarction in the rat. This method enables non-invasive quantification of the extent of the cerebral oedema from T2-weighted spin-echo images. This article reports the evolution of the extent of oedema with time (0.5, 1, 2, 4, 6, 24 and 48 h, 7 and 15 days and 1 month after induction of the lesion) in rats pretreated with 5 mg kg(-1) BM27 or an appropriate control. At all times, the rats treated with BM27 had, on average, smaller lesions than control rats (30% decrease between 2 h and 6 h). These results strongly suggest a significant (P < 0.01) but modest neuroprotective effect of BM27 in ischaemic cerebral stroke. Further investigations should be performed to determine if BM27 or its analogues are of clinical interest.

Document type Article de périodique (Journal article) – Journal Article
Publication date 1999
Journal information "The Journal of pharmacy and pharmacology" - Vol. 51, no. 8, p. 967-70 (1999)
Peer reviewed yes
issn 0022-3573
Publication status Publié
Affiliations UCL - MD/FARM - Ecole de pharmacie
UCL - EUEN/STAT - Institut de statistique
MESH Subject Animals ; Brain Edema - etiology - pathology ; Cerebral Infarction - pathology ; Ischemia - pathology ; Light - adverse effects ; Magnetic Resonance Imaging ; Male ; Neuroprotective Agents - pharmacology ; Rats ; Rats, Wistar ; Sulfonylurea Compounds - pharmacology ; Thrombosis - etiology
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Bibliographic reference Baudelet, Christine ; Demeure, R. ; Frois, A ; Masereel, Bernard ; Goudemant, Jean-François ; et. al. Evidence for a neuroprotective effect of pyrid-3-yl-sulphonyl-urea in photochemically induced focal ischaemia in rats: magnetic resonance imaging evaluation.. In: The Journal of pharmacy and pharmacology, Vol. 51, no. 8, p. 967-70 (1999)
Permanent URL http://hdl.handle.net/2078.1/8363