Etude in vitro de l'adsorption de la chloroquine par un remède antidiarrhéique employé traditionnellement en Afrique

Mouboumou (prepared from the inner part of termitaria) is used in traditional medicine in Zaire in the treatment of diarrhoea. Antimalarials are often used simultaneously with antidiarrhoeal drugs, which might, by their adsorbent properties, compromise the efficacy of the antimalarial treatment. An in vitro study compared the adsorption of chloroquine by Mouboumou and by kaopectate. The adsorption was very marked (from 30 to 60%) and followed Langmuir's equation quite well. It is concluded that a decrease in bioavailability of chloroquine, due to the adsorption, may occur in vivo and could contraindicate the simultaneous administration of chloroquine and mouboumou.