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Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes : a position paper of the Working Group 'Myocardial Function' of the ESC

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Knöll, Ralph Iaccarino, Guido Tarone, Guido Hilfiker-Kleiner, Denise Bauersachs, Johann Balligand, Jean-Luc [UCL]

Many primary or secondary diseases of the myocardium are accompanied with complex remodelling of the cardiac tissue that results in increased heart mass, often identified as cardiac 'hypertrophy'. Although there have been numerous attempts at defining such 'hypertrophy', the present paper delineates the reasons as to why current definitions of cardiac hypertrophy remain unsatisfying. Based on a brief review of the underlying pathophysiology and tissue and cellular events driving myocardial remodelling with or without changes in heart dimensions, as well as current techniques to detect such changes, we propose to restrict the use of the currently popular term 'hypertrophy' to cardiac myocytes that may or may not accompany the more complex tissue rearrangements leading to changes in shape or size of the ventricles, more broadly referred to as 'remodelling'. We also discuss the great potential of genetically modified (mouse) models as tools to define the molecular pathways leading to the different forms of left ventricle remodelling. Finally, we present an algorithm for the stepwise assessment of myocardial phenotypes applicable to animal models using well-established imaging techniques and propose a list of parameters most suited for a critical evaluation of such pathophysiological phenomena in mouse models. We believe that this effort is the first step towards a much auspicated unification of the terminology between the experimental and the clinical cardiologists.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article, Practice Guideline, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "European Journal of Heart Failure" - Vol. 13, no. 8, p. 811-819 (2011)
Peer reviewed yes
Publisher Oxford University Press ((United Kingdom) Oxford)
issn 1388-9842
e-issn 1879-0844
Publication status Publié
Affiliations UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique
UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
MESH Subject Ventricular Remodeling - physiology ; Terminology as Topic ; Phenotype ; Mice ; Hypertrophy, Left Ventricular - physiopathology ; Humans ; Disease Models, Animal ; Cardiomegaly - diagnosis - physiopathology ; Animals ; Algorithms
Links
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Bibliographic reference Knöll, Ralph ; Iaccarino, Guido ; Tarone, Guido ; Hilfiker-Kleiner, Denise ; Bauersachs, Johann ; et. al. Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes : a position paper of the Working Group 'Myocardial Function' of the ESC. In: European Journal of Heart Failure, Vol. 13, no. 8, p. 811-819 (2011)
Permanent URL http://hdl.handle.net/2078.1/81914