User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

The genetic signature of acute leukemia in infacy

Primary tabs

download
  • Open access
  • PDF
  • 549.71 K
Chantrain, Christophe [UCL] Poirel, Hélène [UCL]

Infant leukemia is a rare malignant disease with clinical and biological features distinct from older children. It is characterized by a high incidence of mixed lineage leukemia (MLL) gene rearrangement and a poor outcome despite intensive chemotherapy. Recent genetic studies argue in favor of a unique biology of infant acute leukemia. This review describes the specific genetic signature of infant leukemia. It discusses the important insights it provides into the understanding of leukemogenesis and reviews the influence of genetics on the prognosis and the treatment of leukemia during infancy

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2010
Language Anglais
Journal information "Hem-Onc" - Vol. 1, no. 1, p. 1-8 (2010)
Peer reviewed yes
Publisher Landes Bioscience ((United States) Austin)
issn 2150-5632
e-issn 2150-5640
Publication status Publié
Affiliations UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique
UCL - SSS/DDUV/GEHU - Génétique
Links
Bibliographic reference Chantrain, Christophe ; Poirel, Hélène. The genetic signature of acute leukemia in infacy. In: Hem-Onc, Vol. 1, no. 1, p. 1-8 (2010)
Permanent URL http://hdl.handle.net/2078.1/75487