Pospisil, Jiri
[UCL]
Marko, Istvan
[UCL]
A short and efficient synthesis of (R)-(+)-goniothalamin 1 and (R)-(+)-goniothalamin oxide 2 is described. During this approach, the sulfoxide-modified Julia olefination was used as a key step to connect aldehyde 5 to sulfoxide 6. The desired styryl-containing adduct is obtained in good yield and with excellent E/Z selectivity. (c) 2006 Elsevier Ltd. All rights reserved.
Bibliographic reference |
Pospisil, Jiri ; Marko, Istvan. Total synthesis of (R)-(+)-goniothalamin and (R)-(+)-goniothalamin oxide: first application of the sulfoxide-modified Julia olefination in total synthesis. In: Tetrahedron Letters, Vol. 47, no. 33, p. 5933-5937 (2006) |
Permanent URL |
http://hdl.handle.net/2078.1/69772 |