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Aldehyde Functions in Synthetic Oligonucleotides

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Dechamps, Monique [UCL] Sonveaux, Etienne [UCL]

new nucleoside analogs with a masked aldehyde function have been synthesized and incorporated in oligodexoyribonucleotides. After unmasking the aldehyde function, the oligomers were easily coupled to biotin derivatives by reductive amination. Reversed phase HPLC proved to be an unvaluable tool to characterize and purify these conjugates.

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Publication date 1995
Language Anglais
Conference "11th International Round Table on Nucleosides, Nucleotides and Their Biological Applications", KATHOLIEK UNIV LEUVEN, LEUVEN (Belgium) (Sep 07-11, 1994)
Journal information "Nucleosides and Nucleotides" - Vol. 14, no. 3-5, p. 867-870 (1995)
Peer reviewed yes
issn 0732-8311
Publisher Marcel Dekker Inc (New York)
Affiliation UCL - Autre
Links
Bibliographic reference Dechamps, Monique ; Sonveaux, Etienne. Aldehyde Functions in Synthetic Oligonucleotides.11th International Round Table on Nucleosides, Nucleotides and Their Biological Applications (KATHOLIEK UNIV LEUVEN, LEUVEN (Belgium), Sep 07-11, 1994). In: Nucleosides and Nucleotides, Vol. 14, no. 3-5, p. 867-870 (1995)
Permanent URL http://hdl.handle.net/2078.1/63116