Dewe, W.
Marini, RD
Chiap, P.
Hubert, P.
Crommen, J.
Boulanger, Bruno
For optimizing a liquid chromatographic method, direct modeling some responses like minimum resolution is sometimes difficult to perform. By modeling the retention time at apex and the times associated to 13.4% of the peak height, it is possible to obtain estimations of these responses using an adequate cascade of equations, these equations being the definitions of these responses. As a multi-criteria decision has to be taken in most of these optimizations, a Derringer's function can be defined for each response of interest and a overall desirability, on which the final is taken, can be derived. In addition, the chromatogram in any experimental point can be predicted. (C) 2004 Elsevier B.V. All rights reserved.
Bibliographic reference |
Dewe, W. ; Marini, RD ; Chiap, P. ; Hubert, P. ; Crommen, J. ; et. al. Development of response models for optimising HPLC methods.6th Annual Congress of Chemometrics (Conservatorie Natl Arts & Metiers, Paris
(France), Dec 03-04, 2003). In: Chemometrics and Intelligent Laboratory Systems, Vol. 74, no. 2, p. 263-268 (2004) |
Permanent URL |
http://hdl.handle.net/2078.1/61099 |