Maliverney, C.
Viehe, HG.
Tinant, Bernard
[UCL]
Declercq, Jean-Paul
[UCL]
The reaction of organometallics with trifuorothiopyruvamides or 2-oxo-3,3,3-trifluoropropanethioamides 1 yields the corresponding tertiary alcools, interesting starting materials for new heterocyclizations. Except in the case of the phenyl derivative, the reaction with thionyl chloride does not produce the expected chlorinated derivatives, but allows the easy preparation of alpha-trifluoromethyl-thiocinnamamides. Hydrazine reacts easily with the latter compounds, yielding the corresponding dihydropyrazoles that are easily oxidized into pyrazoles.
Bibliographic reference |
Maliverney, C. ; Viehe, HG. ; Tinant, Bernard ; Declercq, Jean-Paul. [Reactions of Tertiary Alcohols Derived From 2-oxo-3,3,3-trifluoropropanethioamides]. In: Societe Chimique de France. Bulletin, , no. 6, p. 843-848 (1990) |
Permanent URL |
http://hdl.handle.net/2078.1/51262 |