Boualam, M.
Meunierpiret, J.
Biesemans, M.
Willem, R.
Gielen, M.
Dicyclohexyltin(IV) bis(2-pyridylthiolate), compound 1, crystallizes in the orthorhombic system, a = 16.448(3), b = 40.315(8) and c = 7.113(3). Its molecular structure is best described as a tetrahedron, based on the two carbon-tin and the two sulfur-tin bonds, which is however strongly distorted as a consequence of two weak additional nitrogen-tin bonds. Compound 1 and four other diorganotin(IV) bis(2-pyridylthiolates) are characterized by Mossbauer, H-1, C-13 and Sn-119 NMR spectroscopy, and by FAB mass spectrometry. Their in vitro antitumour activity against two human tumour cell lines, MCF-7 and WiDr is reported. The ID50 values found are comparable to those found for cis-platin, but deceptively higher than for many other diorganotin compounds.
Bibliographic reference |
Boualam, M. ; Meunierpiret, J. ; Biesemans, M. ; Willem, R. ; Gielen, M.. Organotin(iv) Compounds of 2-thiopyridine - Crystal and Molecular-structure of Dicyclohexyltin(iv) Bis(2-pyridylthiolate). In: Inorganica Chimica Acta, Vol. 200, p. 249-255 (1992) |
Permanent URL |
http://hdl.handle.net/2078.1/50273 |