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Internalization of Glimepiride and Glibenclamide in the Pancreatic B-cell

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Marynissen, G. Smets, G. Klöppel, G. Gerlache, Louis [UCL] Malaisse, Willy

When rat pancreatic islets were exposed for 30 min at 37-degrees-C to tritiated glibenclamide (2.5 muM) or glimepiride (1.5 muM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 1992
Language Anglais
Journal information "Acta Diabetologica : an international journal devoted to the study of clinical and experimental diabetes and metabolism" - Vol. 29, no. 2, p. 113-114 (1992)
Peer reviewed yes
Publisher Springer Verlag (New York)
issn 0940-5429
e-issn 1432-5233
Publication status Publié
Affiliation UCL - AGRO/MILA - Département des sciences du milieu et de l'aménagement du territoire
Keywords GLIMEPIRIDE ; GLIBENCLAMIDE ; PANCREATIC ISLETS
Links
  1. Geisen K, Special pharmacology of the new sulfonylurea glimepiride. Drug Res 38:1120?1130, 1988
  2. Malaisse WJ, Ionophoretic activity of glimepiride. Med Sci Res 19:353, 1991
  3. Lebrun P, Malaisse WJ, Cationic and secretory effects of glimepiride and glibenclamide in perifused rat islets. Pharmacol Toxicol 70:357?360, 1992
  4. Leclercq-Meyer V, Akkan AG, Marchand J, Malaisse WJ, Effects of glimepiride and glibenclamide on insulin and glucagon secretion by the perfused rat pancreas. Biochem Pharmacol 42:1634?1637, 1991
  5. Carpentier J-L, Sawano F, Ravazzola M, Malaisse WJ, Internalization of3H-glibenclamide in pancreatic islets. Diabetologia 29:259?261, 1986
  6. Malaisse-Lagae F, Malaisse WJ, Insulin release by pancreatic islets. In: Larner R, Pohl SL (eds) Methods in diabetes research. Wiley, New York, pp 147?152, 1984
Bibliographic reference Marynissen, G. ; Smets, G. ; Klöppel, G. ; Gerlache, Louis ; Malaisse, Willy. Internalization of Glimepiride and Glibenclamide in the Pancreatic B-cell. In: Acta Diabetologica : an international journal devoted to the study of clinical and experimental diabetes and metabolism, Vol. 29, no. 2, p. 113-114 (1992)
Permanent URL http://hdl.handle.net/2078.1/50129