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Dialkyltin Derivatives of Dicarboxylic-acids - Synthesis, Characterization and Invitro Antitumor Properties

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Gielen, M. Boualam, M. Meriem, A. Mahieu, Bernard [UCL] Biesemans, M. Willem, R.

Diorganotin derivatives of dicarboxylic acids, including diethyltin propene-1,3-dicarboxylate, diethyltin homophthalate, and di-n-butyltin tetrafluorophthalate, were tested in vitro against two human tumor cell lines, MCF-7, a mammary tumor, and WiDr, a colon carcinoma. Most of these display lower inhibition doses ID50 than cis-platin. The synthesis and characterization of the last three compounds by Mossbauer spectroscopy, H-1, C-13 and/or Sn-119 NMR and mass spectrometry, are also presented.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1992
Language Anglais
Journal information "Heteroatom Chemistry" - Vol. 3, no. 4, p. 449-452 (1992)
Peer reviewed yes
Publisher John Wiley & Sons Inc (New York)
issn 1042-7163
e-issn 1098-1071
Publication status Publié
Affiliation UCL
Links
  1. Bouǎlam, Appl. Organomet. Chem., 4, 335 (1990)
  2. Ross, Anticancer Res., 11, 1089 (1991)
  3. M. Gielen J. Meunier-Piret M. Biesemans R. Willem A. El Khloufi Appl. Organomet. Chem.
  4. M. Bouǎlam M. Gielen A. Meriem D. de Vos R. Willem
  5. M. Gielen H. Pan R. Willem D. de Vos
  6. Meriem, Main Group Met. Chem., 13, 167 (1990)
  7. Zhang Zhengquan, Pan Huade, Hu Chun, Fu Fangxin, Sun Yunhong, Willem Rudolph, Gielent Marcel, Synthesis, characterization andin vitro antitumour properties of complexes of bis(alkoxycarbonylmethyl)tin dibromides with bidentate nitrogen ligands, 10.1002/aoc.590050307
  8. Bouǎlam, Main Group Met. Chem., 14, 41 (1991)
  9. Meriem, Bull. Soc. Chim. Belg., 100, 367 (1991)
  10. Meriem Abdelkader, Willem Rudolph, Biesemans Monique, Mahieu Bernard, de Vos Dick, Lelieveld Peter, Gielen Marcel, Synthesis, characterization andin vitro antitumour activity of di-n-butyltin(;iv) derivatives of some aromatic carboxylic acids, including aspirin, 10.1002/aoc.590050309
  11. Gielen, Chemistry and Technology of Silicon and Tin, 312 (1991)
  12. Bouâlam Mohammed, Willem Rudolph, Biesemans Monique, Mahieu Bernard, Gielen Marcel, Synthesis, characterization, and in vitro antitumor activity of some tin(IV)-oxygen and tin(IV)-sulfur heterocycles : Synthesis, Characterization, and In Vitro Antitumor Activity of Some Tin(IV)-Oxygen and Tin-Sulfur Heterocycles, 10.1002/hc.520020404
  13. Bouâlam Mohammed, Willem Rudolph, Biesemans Monique, Gielen Marcel, Synthesis, characterization andin vitroantitumor activity of dimethyl-, diethyl, and di-t-butyl-tin(IV) derivatives of substituted salicylic acids : DIORGANOTIN(IV) DERIVATIVES OF SALICYLIC ACIDS, 10.1002/aoc.590050607
  14. M. Gielen P. Lelieveld D. de Vos R. Willem In vitro Antitumour Activity of Organotin(IV) Derivatives of Salicylic Acid and Related Compounds Metal Complexes in Cancer Chemotherapy B. K. Keppler VCH
  15. M. Gielen P. Lelieveld D. de Vos R. Willem In vitro Antitumour Activity of Organotin Compounds Metal-Based Antitumour Drugs 2 M. Gielen Freund Publishing House
  16. Bouǎlam, Main Group Met. Chem., 14, 41 (1991)
  17. Van Lambalgen, Invest. New Drugs, 5, 161 (1987)
  18. Bou??lam Mohammed, Willem Rudolph, Gelan Jan, Sebald Angelika, Lelieveld Peter, de Vos Dick, Gielen Marcel, Synthesis, characterization andin vitro antitumour activity of a series of substituted 2,2-di-n-butyl-4-oxo-benzo-1,3,2-dioxastannins, 10.1002/aoc.590040406
  19. Gielen, Main Group Met. Chem., 10, 147 (1987)
  20. Gielen, Main Group Met. Chem., 14, 67 (1991)
  21. Gielen, Bull. Soc. Chim. Belg., 100, 743 (1991)
  22. Gielen Marcel, Mélotte Muriel, Atassi Ghanem, Willem Rudolph, Synthesis, characterization and antitumour activity of 7,7-di-n-butyl-5,9-dioxo-6,8-dioxa-7-stanna-spiro[3,5]nonane, a di-n-butyltin(IV) analog of “paraplatin”, and of a series of di-n-butyltin(IV) derivatives of mono- and disubstltuted malonic acids, 10.1016/0040-4020(89)80030-4
  23. Meriem Abdelkader, Gielen Marcel, Willem Rudolph, Synthesis, characterization and antitumour activity of a series of diorganotin(IV) derivatives of bis(carboxymethyl)amines, 10.1016/0022-328x(89)87170-0
  24. Meriem, Main Group Met. Chem., 12, 187 (1989)
  25. M. Gielen A. Meriem R. Willem
Bibliographic reference Gielen, M. ; Boualam, M. ; Meriem, A. ; Mahieu, Bernard ; Biesemans, M. ; et. al. Dialkyltin Derivatives of Dicarboxylic-acids - Synthesis, Characterization and Invitro Antitumor Properties. In: Heteroatom Chemistry, Vol. 3, no. 4, p. 449-452 (1992)
Permanent URL http://hdl.handle.net/2078.1/50111