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Development of Poly (dialkyl Methylidenemalonate) Nanoparticles As Drug Carriers

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Mbela, TKM. Poupaert, Jacques [UCL] Dumont, Pierre [UCL] Haemers, A.

Two novel dialkylmethylidenemalonate (DAMM) analogs: diallylmethylidenemalonate (AAMM, 1b) and cyclohexylethylmethylidenemalonate (CEMM, 1c) were synthesized and evaluated for their capacity to polymerise to stable nanoparticles and to adsorb primaquine diphosphate (PQ). PQ loading onto poly-AAMM (PAAMM, 1b) and poly-CEMM (PCEMM, 1c) was up to 90% in the pH range from 6.0 to 8.5. A significant improvement of the physicochemical characteristics and the PQ desorption capacity of the nanoparticles was achieved in this series of PDAMM analogs.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1993
Language Anglais
Journal information "International Journal of Pharmaceutics" - Vol. 92, no. 1-3, p. 71-79 (1993)
Peer reviewed yes
Publisher Elsevier Science Bv (Amsterdam)
issn 0378-5173
e-issn 1873-3476
Publication status Publié
Affiliation UCL
Keywords DIALKYLMETHYLIDENEMALONATE ; POLYMETHYLIDENEMALONATE ESTER ; POLY(DIALLYLMETHYLIDENE MALONATE) ; POLY(CYCLOHEXYLETHYLMETHYLIDENE MALONATE) ; NANOPARTICLES ; PRIMAQUINE
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Bibliographic reference Mbela, TKM. ; Poupaert, Jacques ; Dumont, Pierre ; Haemers, A.. Development of Poly (dialkyl Methylidenemalonate) Nanoparticles As Drug Carriers. In: International Journal of Pharmaceutics, Vol. 92, no. 1-3, p. 71-79 (1993)
Permanent URL http://hdl.handle.net/2078.1/49701