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Brain Glucose-metabolism and Dopamine-d(2) Receptor Analysis in a Patient With Hemiparkinsonism-hemiatrophy Syndrome

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Przedborski, S. Goldman, S. Levivier, M. Giladi, N. Bidaut, LM. Labar, Daniel [UCL] Luxen, A.

We report findings on brain glucose metabolism and dopamine D2 receptors generated by positron emission tomography (PET) in a 67-year-old woman with right hemiparkinsonism-hemiatrophy syndrome (HP-HA). PET with [F-18]-fluorodeoxyglucose (FDG) showed marked glucose metabolism asymmetry. There were significant reductions in glucose uptake at the level of the basal ganglia and, to lesser extent, in the fronto-parietal cortex contralateral to the clinically involved side. These changes were different from those found in a patient with hemi-Parkinson's disease who was scanned under similar conditions. Because the patient with HP-HA had only minimal response to levodopa therapy, we evaluated post-synaptic dopaminergic structures using PET with [F-18]-fluoroethylspiperone (FESP). No striatal binding asymmetry was found in FESP/PET, which suggests a sparing of striatal dopamine D2 receptors. The changes in FDG uptake which we found were in brain areas relevant to the clinical features of HP-HA syndrome. In addition, our study provides evidence that FDG/PET may help to differentiate HP-HA syndrome from hemi-Parkinson's disease. In most instances, since HP-HA is associated with a more benign clinical course than Parkinson's disease, this distinction is of clinical important.

Document type Article de périodique (Journal article) – Case Reports, Journal Article
Publication date 1993
Language Anglais
Journal information "Movement Disorders" - Vol. 8, no. 3, p. 391-5 (1993)
Peer reviewed yes
Publisher Lippincott-raven Publ (Philadelphia)
issn 0885-3185
e-issn 1531-8257
Publication status Publié
Affiliation UCL - MD/MINT - Département de médecine interne
MESH Subject Tomography, Emission-Computed ; Spiperone - analogs & derivatives - diagnostic use - metabolism ; Receptors, Dopamine D2 - metabolism ; Parkinson Disease - diagnosis - metabolism - radionuclide imaging ; Humans ; Glucose - metabolism ; Functional Laterality ; Female ; Diagnosis, Differential ; Corpus Striatum - metabolism - radionuclide imaging ; Brain - metabolism - radionuclide imaging ; Basal Ganglia - metabolism - radionuclide imaging ; Aged
Keywords BRAIN GLUCOSE ; DOPAMINE-D(2) ; PET ; HEMI-PARKINSONS DISEASE
Links
  1. Klawans H. L., Hemiparkinsonism as a late complication of hemiatrophy: A new syndrome, 10.1212/wnl.31.5.625
  2. Buchman A. S., Goetz C. G., Klawans H. L., Hemiparkinsonism with hemiatrophy, 10.1212/wnl.38.4.527
  3. Jankovic J., Hemiparkinsonism and hemiatrophy, 10.1212/wnl.38.11.1815
  4. Giladi N., Burke R. E., Kostic V., Przedborski S., Gordon M., Hunt A., Fahn S., Hemiparkinsonism-hemiatrophy syndrome: Clinical and neuroradiologic features, 10.1212/wnl.40.11.1731
  5. Sokoloff, J Neurochem, 28, 897 (1977)
  6. PET studies in parkinsonism. Neurol Clin (in press).
  7. Eidelberg, Mov Disord, 5, 203 (1990)
  8. Barrio Jorge R., Satyamurthy Nagichettiar, Huang Sung-Cheng, Keen Randy E., Nissenson Charna H. K., Hoffman John M., Ackermann Robert F., Bahn Mark M., Mazziotta John C., Phelps Michael E., 3-(2'-[18F]Fluoroethyl)Spiperone: In vivo Biochemical and Kinetic Characterization in Rodents, Nonhuman Primates, and Humans, 10.1038/jcbfm.1989.117
  9. et al. Positron emission tomography-guided stereotaxic brain biopsy. Neurosurgery (in press).
  10. Padgett, Appl Radiat Isot, 40, 433 (1989)
  11. Hamacher, J Nucl Med, 27, 235 (1986)
  12. Phelps, Ann Neurol, 6, 371 (1979)
  13. Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical Publisher Inc., 1988.
  14. Plenevaux, J Labelled Compd Radiopharm, 30, 382 (1991)
  15. Duara, Brain, 106, 761 (1983)
  16. Pickel, Brain Res, 225, 373 (1981)
  17. Tennyson, Brain Res, 82, 341 (1974)
  18. Gerfen, Trends Neurosci, 15, 133 (1992)
  19. Goffinet, Ann Neurol, 25, 131 (1989)
  20. Karbe H., Herholz K., Szelies B., Pawlik G., Wienhard K., Heiss W.-D., Regional metabolic correlates of Token test results in cortical and subcortical left hemispheric infarction, 10.1212/wnl.39.8.1083
  21. Martin W.R.W., Beckman J.H., Calne D.B., Adam M.J., Harrop R., Rogers J.G., Ruth T.J., Sayre C.I., Pate B.D., Cerebral Glucose Metabolism in Parkinson’s Disease, 10.1017/s0317167100046357
  22. Eidelberg, J Neurol Neurosurg Psychiatry, 54, 856 (1991)
  23. Rinne, Mov Disord, 5, 55 (1990)
Bibliographic reference Przedborski, S. ; Goldman, S. ; Levivier, M. ; Giladi, N. ; Bidaut, LM. ; et. al. Brain Glucose-metabolism and Dopamine-d(2) Receptor Analysis in a Patient With Hemiparkinsonism-hemiatrophy Syndrome. In: Movement Disorders, Vol. 8, no. 3, p. 391-5 (1993)
Permanent URL http://hdl.handle.net/2078.1/49646