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Stable Chromosome-aberrations 25 Years After Severe Accidental Radiation Exposure

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Maes, Andrée [UCL] Hilali, A. Leonard, ED. Leonard, A. [UCL] Verschaeve, L.

A thorough cytogenetic analysis using G-banding was performed on 100 peripheral blood lymphocytes from an individual who had been accidentally exposed to radiation more than 25 years previously. More than 60% of the analysed cells were found to possess one or more stable chromosome aberrations (e.g. reciprocal translocations). Chromosomes 1 and 11 were more involved in these aberrations than would be expected from the relative chromosome lengths. No identical stable aberrations were found, suggesting that, 25 years after near-lethal exposure, haemopoietic stem cells display substantial diversity.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1993
Language Anglais
Journal information "Radiation and Environmental Biophysics" - Vol. 32, no. 4, p. 319-324 (1993)
Peer reviewed yes
Publisher Springer Verlag (New York)
issn 0301-634X
e-issn 1432-2099
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
Links
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Bibliographic reference Maes, Andrée ; Hilali, A. ; Leonard, ED. ; Leonard, A. ; Verschaeve, L.. Stable Chromosome-aberrations 25 Years After Severe Accidental Radiation Exposure. In: Radiation and Environmental Biophysics, Vol. 32, no. 4, p. 319-324 (1993)
Permanent URL http://hdl.handle.net/2078.1/49421