User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Crystal-structure and Solid-state Conformation of 5-hydroxy-8,9-dioxo-8,9-seco-5-alpha-cholestan-3-beta-yl Acetate

Primary tabs

Tinant, Bernard [UCL] Declercq, Jean-Paul [UCL] Dabovic, M. Krstic, N. Lorenc, L. Mihailovic, ML.

The molecular structure of the title compound, which might be a possible intermediate in the synthesis of 5,10:8,9-diseco-steroids (=steroklastanes), was determined by X-ray analysis. Hydrogen bonding between the 5alpha-hydroxyl group and the 9-oxo function attached to the ten-membered ring, and the presence of two conformational forms of the side-chain in the solid state structure of 2 are established.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1993
Language Anglais
Journal information "Societes Chimiques Belges. Bulletin" - Vol. 102, no. 8, p. 539-544 (1993)
Peer reviewed yes
Publisher Soc Chimique Belgique (Brussels)
issn 0037-9646
Publication status Publié
Affiliation UCL
Links
  1. Lorenc, Helv. Chim. Acta, 72, 608 (1989)
  2. Lorenc , Lj. Bondarenko-Gheorghiu , L. Pavlovic , V. Fuhrer , H. Kalvoda , J. Mihailovic , M. Lj. 1992 Helv. Chim. Acta. 203 209
  3. Sheldrick G. M., Phase annealing in SHELX-90: direct methods for larger structures, 10.1107/s0108767390000277
  4. Sheldrick , G. M. 1993 J. Appl. Cryst
  5. Motherwell, PLUTO (1978)
  6. Klyne, Exprerientia, XVI, 521 (1960)
  7. Hendrickson, J. Am. Chem. Soc., 89, 7036 (1967)
  8. Altona, Tetrahedron, 24, 13 (1968)
  9. Castellano, Acta Cryst., C45, 966 (1989)
Bibliographic reference Tinant, Bernard ; Declercq, Jean-Paul ; Dabovic, M. ; Krstic, N. ; Lorenc, L. ; et. al. Crystal-structure and Solid-state Conformation of 5-hydroxy-8,9-dioxo-8,9-seco-5-alpha-cholestan-3-beta-yl Acetate. In: Societes Chimiques Belges. Bulletin, Vol. 102, no. 8, p. 539-544 (1993)
Permanent URL http://hdl.handle.net/2078.1/49414