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Cyclosporine-a in the Treatment of Refractory B-chronic Lymphocytic-leukemia (b-cll)

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Van Den Neste, Eric [UCL] Ferrant, Augustin [UCL] Maerevoet, M. Martiat, P. Delannoy, André [UCL] Michaux, JL.

Partial tumoral responses have been described after cyclosporin A treatment in refractory B-chronic lymphocytic leukemia patients. We report the effect of this therapy in five patients prospectively treated with oral conventional dose of cyclosporin A. Antitumoral efficiency was marginal (one sustained partial response among five patients) which, added to a potential worsening of natural and therapy-related immunodepression, limits its use in this instance.

Document type Article de périodique (Journal article)
Publication date 1995
Language Anglais
Journal information "Leukemia" - Vol. 9, no. 6, p. 1102-1103 (1995)
Peer reviewed yes
Publisher Stockton Press (Basingstoke)
issn 0887-6924
e-issn 1476-5551
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL - MD/MINT - Département de médecine interne
Keywords CYCLOSPORINE A ; CHRONIC LYMPHOCYTIC LEUKEMIA-B ; MDR ; AUTOIMMUNE CYTOPENIAS
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Bibliographic reference Van Den Neste, Eric ; Ferrant, Augustin ; Maerevoet, M. ; Martiat, P. ; Delannoy, André ; et. al. Cyclosporine-a in the Treatment of Refractory B-chronic Lymphocytic-leukemia (b-cll). In: Leukemia, Vol. 9, no. 6, p. 1102-1103 (1995)
Permanent URL http://hdl.handle.net/2078.1/47948