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5-Aminopyrazoles from enolisable ketones and 1-cyano-1-alkylhydrazines.

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Ryckmans, T. Viehe, HG. Feneau- Dupont, J. [autre] Tinant, Bernard [UCL] Declercq, Jean-Paul [UCL]

The reaction of enolisable ketones with 1-alkyl-1-cyanohydrazines leads to the corresponding cyanohydrazones. These compounds cyclise under thermal or mildly basic conditions, furnishing the corresponding 5-aminopyrazoles in good yield. In some cases, the hydrazones cannot be isolated and the pyrazole derivatives are directly obtained. Hydrazone-enehydrazine tautomerism was observed, bat no subsequent [3,3]rearrangement. (C) 1997, Elsevier Science Ltd.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1997
Language Anglais
Journal information "Tetrahedron" - Vol. 53, no. 5, p. 1729-1734 (1997)
Peer reviewed yes
Publisher Pergamon-elsevier Science Ltd (Oxford)
issn 0040-4020
e-issn 1464-5416
Publication status Publié
Affiliation UCL
Links
Bibliographic reference Ryckmans, T. ; Viehe, HG. ; Feneau- Dupont, J. ; Tinant, Bernard ; Declercq, Jean-Paul. 5-Aminopyrazoles from enolisable ketones and 1-cyano-1-alkylhydrazines.. In: Tetrahedron, Vol. 53, no. 5, p. 1729-1734 (1997)
Permanent URL http://hdl.handle.net/2078.1/46509