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Uracil derivatives and analogues .24. Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils - their antiviral and cytotoxic activities

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Kundu, NG Das, P. Balzarini, Jan [KUL] De Clercq, Etienne [UCL]

[E]-6-(2-Acylvinyl)uracils and their corresponding 1-(2-hydroxyethoxy)methyl derivatives were synthesized through palladium-catalyzed reactions which involved an interesting rearrangement. Some of the acylvinyl uracils (3, 4, and 5) and the acyclonucleosides (8 and 10) showed pronounced activity against human T-lymphocyte Molt 4/C8 and CEM cells. However, they were less toxic to murine L1210 and FM3A cells. The compounds did not have any marked antiviral activity. (C) 1997 Elsevier Science Ltd.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1997
Language Anglais
Journal information "Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology" - Vol. 5, no. 11, p. 2011-2018 (1997)
Peer reviewed yes
Publisher Pergamon-elsevier Science Ltd (Oxford)
issn 0968-0896
e-issn 1464-3391
Publication status Publié
Affiliation UCL - MD/ESP - Ecole de santé publique
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Bibliographic reference Kundu, NG ; Das, P. ; Balzarini, Jan ; De Clercq, Etienne. Uracil derivatives and analogues .24. Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils - their antiviral and cytotoxic activities. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 5, no. 11, p. 2011-2018 (1997)
Permanent URL http://hdl.handle.net/2078.1/45844