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Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain

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Foury, Françoise [UCL]

Deletion of the yeast frataxin homologue, YFH1, elicits accumulation of iron in mitochondria and mitochondrial defects. We report here that in the presence of an iron chelator in the culture medium, the concentration of iron in mitochondria is the same in wild-type and YFH1 deletant strains, Under these conditions, the activity of the respiratory complexes is restored. However, the activity of the mitochondrial aconitase, a 4Fe-4S cluster-containing protein, remains low, The frataxin family bears homology to a bacterial protein family which confers resistance to tellurium, a metal closely related to sulfur, Yfh1p might control the synthesis of iron-sulfur clusters in mitochondria, (C) 1999 Federation of European Biochemical Societies.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1999
Language Anglais
Journal information "FEBS Letters" - Vol. 456, no. 2, p. 281-284 (1999)
Peer reviewed yes
Publisher Elsevier Science Bv (Amsterdam)
issn 0014-5793
e-issn 1873-3468
Publication status Publié
Affiliation UCL - AGRO/CABI - Département de chimie appliquée et des bio-industries
Keywords Friedreich's ataxia ; mitochondrion ; aconitase ; iron ; tellurium
Links
  1. Kispal Gyula, Csere Peter, Guiard Bernard, Lill Roland, The ABC transporter Atm1p is required for mitochondrial iron homeostasis, 10.1016/s0014-5793(97)01414-2
  2. Knight Simon A. B., Sepuri Naresh Babu V., Pain Debkumar, Dancis Andrew, Mt-Hsp70 Homolog, Ssc2p, Required for Maturation of Yeast Frataxin and Mitochondrial Iron Homeostasis, 10.1074/jbc.273.29.18389
  3. Branda S., Mitochondrial intermediate peptidase and the yeast frataxin homolog together maintain mitochondrial iron homeostasis in Saccharomyces cerevisiae, 10.1093/hmg/8.6.1099
  4. Babcock M., Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin, 10.1126/science.276.5319.1709
  5. Foury Françoise, Cazzalini Ornella, Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria, 10.1016/s0014-5793(97)00734-5
  6. Wilson Robert B., Roof David M., Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue, 10.1038/ng0897-352
  7. Koutnikova Hana, Campuzano Victoria, Foury Françoise, Dollé Pascal, Cazzalini Ornella, Koenig Michel, Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin, 10.1038/ng0897-345
  8. Radisky Derek C., Babcock Michael C., Kaplan Jerry, The Yeast Frataxin Homologue Mediates Mitochondrial Iron Efflux : EVIDENCE FOR A MITOCHONDRIAL IRON CYCLE, 10.1074/jbc.274.8.4497
  9. Rötig Agnès, de Lonlay Pascale, Chretien Dominique, Foury Françoise, Koenig Michel, Sidi Daniel, Munnich Arnold, Rustin Pierre, Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia, 10.1038/ng1097-215
  10. Campuzano V., Montermini L., Molto M. D., Pianese L., Cossee M., Cavalcanti F., Monros E., Rodius F., Duclos F., Monticelli A., Zara F., Canizares J., Koutnikova H., Bidichandani S. I., Gellera C., Brice A., Trouillas P., De Michele G., Filla A., De Frutos R., Palau F., Patel P. I., Di Donato S., Mandel J.-L., Cocozza S., Koenig M., Pandolfo M., Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion, 10.1126/science.271.5254.1423
  11. Koutnikova Hana, Campuzano Victoria, Foury Françoise, Dollé Pascal, Cazzalini Ornella, Koenig Michel, Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin, 10.1038/ng0897-345
  12. Tangerås Arild, Flatmark Torgeir, Bäckström Dan, Ehrenberg Anders, Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state, 10.1016/0005-2728(80)90035-3
  13. Beinert H., Iron-Sulfur Clusters: Nature's Modular, Multipurpose Structures, 10.1126/science.277.5326.653
  14. Gibson Toby J., Koonin Eugene V., Musco Giovanna, Pastore Annalisa, Bork Peer, Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction, 10.1016/s0166-2236(96)20054-2
  15. Taylor Diane E., Bacterial tellurite resistance, 10.1016/s0966-842x(99)01454-7
  16. Altschul S., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, 10.1093/nar/25.17.3389
  17. Walter Emily G., Taylor Diane E., Plasmid-mediated resistance to tellurite: Expressed and cryptic, 10.1016/0147-619x(92)90006-v
  18. Rouault Tracey A., Klausner Richard D., Iron-sulfur clusters as biosensors of oxidants and iron, 10.1016/s0968-0004(96)10024-4
  19. Strain Jeffrey, Lorenz Carrie R., Bode Jacqueline, Garland Stacey, Smolen Gromoslaw A., Ta Dennis T., Vickery Larry E., Culotta Valeria Cizewski, Suppressors of Superoxide Dismutase (SOD1) Deficiency inSaccharomyces cerevisiae : IDENTIFICATION OF PROTEINS PREDICTED TO MEDIATE IRON-SULFUR CLUSTER ASSEMBLY, 10.1074/jbc.273.47.31138
  20. Zheng L., White R. H., Cash V. L., Jack R. F., Dean D. R., Cysteine desulfurase activity indicates a role for NIFS in metallocluster biosynthesis., 10.1073/pnas.90.7.2754
  21. Zheng, J. Biol. Chem., 269, 18723 (1994)
  22. Flint Dennis H., Tuminello Joseph F., Miller Thomas J., Studies on the Synthesis of the Fe-S Cluster of Dihydroxy-acid Dehydratase inEscherichia coliCrude Extract : ISOLATION OFO-ACETYLSERINE SULFHYDRYLASES A AND B AND β-CYSTATHIONASE BASED ON THEIR ABILITY TO MOBILIZE SULFUR FROM CYSTEINE AND TO PARTICIPATE IN Fe-S CLUSTER SYNTHESIS, 10.1074/jbc.271.27.16053
  23. Zheng Limin, Cash Valerie L., Flint Dennis H., Dean Dennis R., Assembly of Iron-Sulfur Clusters : IDENTIFICATION OF ANiscSUA-hscBA-fdxGENE CLUSTER FROMAZOTOBACTER VINELANDII, 10.1074/jbc.273.21.13264
  24. Land Tiit, Rouault Tracey A., Targeting of a Human Iron–Sulfur Cluster Assembly Enzyme, nifs, to Different Subcellular Compartments Is Regulated through Alternative AUG Utilization, 10.1016/s1097-2765(00)80295-6
  25. Nakai Yumi, Yoshihara Yoshihiro, Hayashi Hideyuki, Kagamiyama Hiroyuki, cDNA cloning and characterization of mousenifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins, 10.1016/s0014-5793(98)00897-7
  26. Kispal Gyula, Csere Peter, Prohl Corinna, Lill Roland, The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins, 10.1093/emboj/18.14.3981
Bibliographic reference Foury, Françoise. Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain. In: FEBS Letters, Vol. 456, no. 2, p. 281-284 (1999)
Permanent URL http://hdl.handle.net/2078.1/44246