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Novel Philadelphia variant t(Y;9;22)(q12;q34;q11) in a case of chronic myeloid leukemia

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Dierlamm, J. Michaux, Lucienne [UCL] Stefanova, M. Eggert, J Leberecht, P Hossfeld, DK

A novel Philadelphia (Ph) variant translocation, t(Y:9:22)(q12;q34;q11), was detected in a 63-year-old man with a newly diagnosed chronic myeloid leukemia (CML). Reverse transcription poly polymerase chain reaction (RT-PCR) analysis revealed a b3a2 fusion transcript. Fluorescence in situ hybridization (FISH) utilizing library probes, subtelomeric cosmid probes, and probes hybridizing to the ABL and BCR genes showed a reciprocal three-way translocation involving Yq12, 9q34, and 22q11, and a BCR-ABL fusion signal on der(22). The subtelomeric Yq probe hybridizing centromerically to the IL9 receptor gene and covering the centromeric portion of the SYBL1 gene was found to be translocated to der(9). (C) Elsevier Science Inc., 1999. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1999
Language Anglais
Journal information "Cancer Genetics and Cytogenetics" - Vol. 114, no. 2, p. 150-153 (1999)
Peer reviewed yes
Publisher Elsevier Science Inc (New York)
issn 0165-4608
e-issn 1873-4456
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL - MD/MINT - Département de médecine interne
Links
Bibliographic reference Dierlamm, J. ; Michaux, Lucienne ; Stefanova, M. ; Eggert, J ; Leberecht, P ; et. al. Novel Philadelphia variant t(Y;9;22)(q12;q34;q11) in a case of chronic myeloid leukemia. In: Cancer Genetics and Cytogenetics, Vol. 114, no. 2, p. 150-153 (1999)
Permanent URL http://hdl.handle.net/2078.1/44106