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Di-n-butyltin(IV) derivatives of bis(carboxymethyl)benzylamines: synthesis, NMR and X-ray structure characterization and in vitro antitumour properties

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Mancilla, T Carrillo, L Rivera, LSZ Camacho, CC De Vos, D. Mahieu, Bernard [UCL] Willem, R.

Four di-n-butyltin(IV) derivatives of bis(carboxymethyl)benzylamines were synthesized and their structure characterized by H-1,C-13 and Sn-117/119 NMR, Mossbauer spectroscopy and mass spectrometry, The derivative substituted in the meta position by a methyl group has been further characterized by X-ray crystallography, This compound exhibits a distorted trigonal bipyramidal geometry at tin. The NMR data in solution, as well as other spectroscopic results in the solid state, confirm this structure for all the compounds. Evidence is provided to show that the compounds are more highly associated in concentrated solution than in the solid state. Their in vitro antitumour activity is reported. Copyright (C) 2001 John Wiley & Sons, Ltd.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2001
Language Anglais
Journal information "Applied Organometallic Chemistry" - Vol. 15, no. 7, p. 593-603 (2001)
Peer reviewed yes
Publisher John Wiley & Sons Ltd (W Sussex)
issn 0268-2605
e-issn 1099-0739
Publication status Publié
Affiliation UCL - SC/CHIM - Département de chimie
Keywords butyltin ; benzylamines ; structure ; NMR ; Mossbauer ; mass spectroscopy
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Bibliographic reference Mancilla, T ; Carrillo, L ; Rivera, LSZ ; Camacho, CC ; De Vos, D. ; et. al. Di-n-butyltin(IV) derivatives of bis(carboxymethyl)benzylamines: synthesis, NMR and X-ray structure characterization and in vitro antitumour properties. In: Applied Organometallic Chemistry, Vol. 15, no. 7, p. 593-603 (2001)
Permanent URL http://hdl.handle.net/2078.1/42673