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Serum pneumoproteins: A cross-sectional comparison of firefighters and police

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Burgess, JL Witten, ML Nanson, CJ Hysong, TA Sherrill, DL Bernard, AM.

Background Serum pneumoproteins provide a measure of the permeability of the lower respiratory tract, and have shown promise as a biomarker of acute and chronic exposure to respiratory toxicants. Methods To evaluate the effects of chronic occupational smoke exposure, 105 firefighters were compared with 44 police controls in a cross-sectional study using spirometry, diffusing capacity of the lung, serum Clara cell protein (CC16), and serum surfactant-associated protein A (SP-A) measurements. Results There were no significant differences in age, gender, height, spirometry (FVC and FEVI), and diffusing capacity between the two groups. Serum SP-A was lower in firefighters (260.1 +/- 121.2 mug/L) than police (316.0 +/- 151.4 mug/L, P = 0.019). Serum CC16 was also lower in firefighters (8.39 +/- 3.11 mug/L) than police (10.56 +/- 4.20 mug/L, P < 0.001), although this difference lost statistical significance when adjusted for confounders. Conclusions Firefighters have lower serum concentrations of SP-A than do police. Although the clinical significance of this finding is presently unknown, SP-A deserves further study as a biomarker of toxic exposure to the lower respiratory tract. (C) 2003 Wiley-Liss, Inc.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2003
Language Anglais
Journal information "American Journal of Industrial Medicine" - Vol. 44, no. 3, p. 246-253 (2003)
Peer reviewed yes
Publisher Wiley-liss (New York)
issn 0271-3586
e-issn 1097-0274
Publication status Publié
Affiliation UCL
Keywords Clara cell-specific protein ; pulmonary surfactant associated protein ; spirometry ; police ; firefighters
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Bibliographic reference Burgess, JL ; Witten, ML ; Nanson, CJ ; Hysong, TA ; Sherrill, DL ; et. al. Serum pneumoproteins: A cross-sectional comparison of firefighters and police. In: American Journal of Industrial Medicine, Vol. 44, no. 3, p. 246-253 (2003)
Permanent URL http://hdl.handle.net/2078.1/40817