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Bicyclo[2.2-1]heptanes as novel triple re-uptake inhibitors for the treatment of depression

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Axford, L Boot, JR Hotten, TM Keenan, M Martin, FM Vivien, V

A series of substituted naphthyl containing chiral [2.2.1] bicycloheptanes were prepared utilizing asymmetric Diels-Alder chemistry. This paper describes structure-activity relationships in this series. The N-methyl 2-naphthyl analogue (16d) and its desmethyl analogue (17d) are active triple re-uptake inhibitors both in vivo and in vitro. (C) 2003 Elsevier Ltd. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Language Anglais
Journal information "Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology" - Vol. 13, no. 19, p. 3277-3280 (2003)
Peer reviewed yes
Publisher Pergamon-elsevier Science Ltd (Oxford)
issn 0960-894X
e-issn 1464-3405
Publication status Publié
Affiliation UCL
Links
Bibliographic reference Axford, L ; Boot, JR ; Hotten, TM ; Keenan, M ; Martin, FM ; et. al. Bicyclo[2.2-1]heptanes as novel triple re-uptake inhibitors for the treatment of depression. In: Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 13, no. 19, p. 3277-3280 (2003)
Permanent URL http://hdl.handle.net/2078.1/40798