Three antibiotics sulfafurazole (SFZ), sulfamethoxazole (SMZ) and sulfacetamide sodium (SSA-Na) belonging to sulfonamides were irradiated and changes in physico-chemical properties, pH, melting points, UV, IR, NMR, TLC, GC-MS, ESR characteristics, antimicrobial activities of active components were studied at normal and accelerated stability test conditions. Two radiolytic intermediates for both SFZ and SMZ and four radiolytic intermediates for SSA-Na were found in the irradiated solid samples after the GC-MS analysis. The results obtained under normal and accelerated stability test conditions were observed to be consistent with the unirradiated values. (C) 2003 Elsevier Ltd. All rights reserved.
Mercanoglu, Olguner G. ; Ozer, A.Y. ; Colak, S. ; Korkmaz, M. ; Ozalp, M. ; et. al. Radiosterilization of sulfonamides: I: determination of the effects of gamma irradiation on solid sulfonamides. In: Radiation Physics and Chemistry, Vol. 69, no. 6, p. 511-520 (2004)
