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Nitric oxide synthases II and III and vascular endothelial growth factor are up-regulated in sciatic nerve after spiral cuff electrode implantation

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Thil, Marie-Anne [UCL] Vince, Valérie [UCL] Veraart, Claude [UCL] Delbeke, Jean [UCL] Colin, IM [UCL]

Nerve cuff electrodes, commonly used in functional electrical stimulation systems, induce local morphological changes that can affect nerve functionality. Nitric oxide (NO) and vascular endothelial growth factor (VEGF) have both neural and vascular effects. We investigated the time-dependent regulation of nitric oxide synthases (NOS) and of VEGF after implantation of spiral cuff electrode around rat sciatic nerve. NOSIII as well as VEGF were up-regulated in both epineurial and endoneurial compartments in cuff-implanted animals along with microvascular changes. Our results suggest that VEGF and NO are implied in morphological and functional alterations occurring in the early time after cuff implantation. (C) 2005 Elsevier B.V. All rights reserved.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Journal of Neuroimmunology" - Vol. 166, no. 1-2, p. 158-66 (2005)
Peer reviewed yes
Publisher Elsevier Science Bv (Amsterdam)
issn 0165-5728
e-issn 1872-8421
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
MESH Subject Vascular Endothelial Growth Factor A - metabolism ; Up-Regulation ; Sciatic Nerve - blood supply - metabolism - pathology ; Rats ; Nitric Oxide Synthase Type III ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase - metabolism ; Neuritis - etiology - pathology ; Microcirculation ; Immunohistochemistry ; Electrodes, Implanted ; Blotting, Western ; Blood Vessels - metabolism - pathology ; Animals
Keywords spiral cuff electrode ; nitric oxide synthase (NOS) ; vascular endothelial growth factor (VEGF) ; immunohistochemistry ; western blot
Links
Bibliographic reference Thil, Marie-Anne ; Vince, Valérie ; Veraart, Claude ; Delbeke, Jean ; Colin, IM. Nitric oxide synthases II and III and vascular endothelial growth factor are up-regulated in sciatic nerve after spiral cuff electrode implantation. In: Journal of Neuroimmunology, Vol. 166, no. 1-2, p. 158-66 (2005)
Permanent URL http://hdl.handle.net/2078.1/39144