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Pharmacokinetic interaction between valproic acid and meropenem

  1. Coves-Orts FJ, Borras-Blasco J, Navarro-Ruiz A, Murcia-Lopez A, Palacios-Ortega F (2005) Acute seizures due to a probable interaction between valproic acid and meropenem. Ann Pharmacother 39:533–537
  2. Llinarez Tello F, Bosacoma Ros N, Hernandez Prats C, Climent Grana E, Selva Otaolaurruchi J, Ordovas Baines JP (2003) Pharmacokinetic interaction between valproic acid and meropenem. Farm Hosp 27:258–263
  3. De Turck BJ, Diltoer MW, Cornelis PJ, Maes V, Spapen HD, Camu F, Huyghens LP (1998) Lowering of plasma valproic acid concentrations during concomitant therapy with meropenem and amikacin. J Antimicrob Chemother 42:563–564
  4. Nacarkucuk E, Saglam H, Okan M (2004) Meropenem decreases serum level of valproic acid. Pediatr Neurol 31:232–234
  5. Nagai K, Shimuzu T, Togo A, Takeya M, Yokomizo Y, Sakata UY, Matsuishi T, Kato H (1997) Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/betamipron. J Antimicrob Chemother 39:295–296
  6. Nakajima Y, Mizobuchi M, Nakamura M, Takagi H, Inagaki H, Kominami G, Koike M, Yamaguchi T (2004) Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats. Drug Metab Dispos 32:1383–1391
Bibliographic reference Clause, Didier ; Decleire, Pierre-Yves ; Vanbinst, Roger ; Soyer, Aurélie ; Hantson, Philippe. Pharmacokinetic interaction between valproic acid and meropenem. In: Intensive Care Medicine, Vol. 31, no. 9, p. 1293-1294 (2005)
Permanent URL http://hdl.handle.net/2078.1/39116