User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data

Primary tabs

Yankeelov, Thomas E. Cron, Greg O. Addison, Christina L. Wallace, Julia C. Wilkins, Ruth C. Gore, John C.

Models have been developed for analyzing dynamic contrast-enhanced (DCE)-MRI data that do not require measurements of the arterial input function (AIF). In this study, experimental results obtained from a reference region (FIR) analysis are compared with results of an AIF analysis in the same set of five animals (four imaged twice, yielding nine data sets), returning estimates of the volume transfer constant (K-trans) and the extravascular extracellular volume fraction (v,). Student's t-test values for comparisons of K-trans and v(e) between the two models were 0.14 (P = 0.88) and 0.85 (P > 0.4), respectively (where the high P-values indicate no significant difference between values derived from the two models); Linear regression analysis indicated there was a correlation between K-trans extracted by the two methods: r(2) = 0.80, P = 0.001 (where the low P value indicates a significant linear correlation). For v. there was no such correlation (r(2) = 0.02). The mean (absolute) percent difference between the models was 22.0% for K-trans and 28.1% for v(e). However, the FIR parameter values were much less precise than the AIF method. The mean SDs for K-trans and v(e) for the RR analysis were 0.024 min(-1) and 0.06, respectively, vs. 0.002 min(-1) and 0.03 for AIF analysis. Magn Reson Med 57:353-361, 2007. (c) 2007 Wiley-Liss, Inc.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2007
Language Anglais
Journal information "Magnetic Resonance in Medicine" - Vol. 57, no. 2, p. 353-361 (2007)
Peer reviewed yes
Publisher John Wiley & Sons Inc (Hoboken)
issn 0740-3194
e-issn 1522-2594
Publication status Publié
Affiliation UCL
Keywords DCE-MRI ; tumor pharmacokinetics ; reference region ; arterial input function ; contrast agent
Links
  1. Choyke, J Magn Reson Imaging, 17, 509 (2003)
  2. Tofts, J Magn Reson Imaging, 10, 223 (1999)
  3. Lankester, Br J Cancer, 31, 979 (2005)
  4. Li, J Magn Reson Imaging, 22, 511 (2005)
  5. Wang, Acta Radiol, 46, 353 (2005)
  6. Kovar, J Magn Reson Imaging, 8, 1126 (1998)
  7. Yang, Magn Reson Med, 52, 1110 (2004)
  8. Riabkov, IEEE Trans Biomed Eng, 49, 1318 (2002)
  9. Yankeelov, Magn Reson Imaging, 23, 519 (2005)
  10. Lammertsma, J Cereb Blood Flow Metab, 16, 42 (1999)
  11. Harrer, J Magn Reson Imaging, 20, 748 (2004)
  12. Su, Magn Reson Med, 36, 868 (1996)
  13. , , , , , , . Does measurement of the arterial input function improve the correlation between tumor microvessel density and MR derived perfusion of small molecular extracellular Gd chelates? In: Proceedings of the 12th Annual Meeting of ISMRM, Kyoto, Japan, 2004 (Abstract 1965).
  14. Cron, Magn Reson Med, 51, 1066 (2004)
  15. Cron, Magn Reson Imaging, 23, 619 (2005)
  16. Donahue, Magn Reson Med, 34, 423 (1995)
  17. , , , , . Reproducibility of the reference region method for the analysis of DCE-MRI data. In: Proceedings of the 13th Annual Meeting of ISMRM, Miami Beach, FL, USA, 2005 (Abstract 2104).
  18. Yankeelov, Magn Reson Med, 50, 1151 (2003)
  19. , , . Numerical recipes in C: the art of scientific computing. Cambridge: Cambridge University Press; 1988. p 548–551.
  20. Bland J M., Altman D. G, Statistics Notes: Measurement error proportional to the mean, 10.1136/bmj.313.7049.106
  21. Graff, Magn Reson Imaging, 9, 961 (2005)
  22. Li, J Magn Reson Imaging, 22, 511 (2005)
  23. McIntyre, NMR Biomed, 17, 132 (2004)
  24. Galbraith, J Clin Oncol, 21, 2831 (2003)
  25. Edelstein, Magn Reson Med, 3, 604 (1986)
  26. Black, Science, 259, 793 (1993)
  27. . Fundamentals of nuclear magnetic resonance. Essex: Longman Scientific and Technical; 1993. p 104–105.
  28. Simpson, Magn Reson Med, 42, 42 (1999)
  29. Li, Proc SPIE Symp Med Imaging, 6144, 6144ot (2006)
  30. Landis, Magn Reson Med, 44, 563 (2000)
  31. , , . Incorporating the effects of transcytolemmal water exchange in the reference region model for DCE-MRI analysis. In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, USA, 2006 (Abstract 390).
Bibliographic reference Yankeelov, Thomas E. ; Cron, Greg O. ; Addison, Christina L. ; Wallace, Julia C. ; Wilkins, Ruth C. ; et. al. Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. In: Magnetic Resonance in Medicine, Vol. 57, no. 2, p. 353-361 (2007)
Permanent URL http://hdl.handle.net/2078.1/37781