Air-accelerated enantioselective hydrosilylation of ketones catalyzed by copper(I) fluoride-diphosphine complexes: Investigations of the effects of temperature and ligand structure

The fluorotris(triphenylphosphine)copper(I)-bis(methanol) complex-chiral diphosphine system catalyzes the hydrosilylation of several alkyl aryl ketones with moderate to excellent enantioselectivity. An oxygen acceleration effect was observed and led to a practical protocol with low catalyst loading. Optimizations of enantioselectivities (< 95%) and catalytic ratio (< 0.05 mol%) were obtained with bulky Ar-MeO-BIPHEP ligands.