De Reyck, Bert
[UCL]
Leus, Roel
[UCL]
An R&D project typically consists of several stages. Due to technological risks, the project may have to be terminated before completion, each stage having a specific likelihood of success. In the project planning and scheduling literature, this technological uncertainty has typically been ignored and project plans are developed only for scenarios in which the project succeeds. In this paper we examine how to schedule projects in order to maximize their expected net p resent value when the project activities have a probability of failure and when an activity's failure leads to overall project termination. We formulate the problem, show that it is NP-hard, develop a A branch-and-bound algorithm that allows us to obtain optimal solutions and provide extensive computational results. In the process, we establish a complexity result for an open problem in single-machine scheduling, namely for the discounted weighted-completion-time objective with general precedence constraints.
- Abernathy William J., Rosenbloom Richard S., Parallel Strategies in Development Projects, 10.1287/mnsc.15.10.b486
- Adlakha V. G., INFOR, 27, 272 (1989)
- Bard Jonathan F., Parallel Funding of R&D Tasks with Probabilistic Outcomes, 10.1287/mnsc.31.7.814
- Bartusch M., Möhring R. H., Radermacher F. J., Scheduling project networks with resource constraints and time windows, 10.1007/bf02283745
- Blau Gary, Mehta Bharat, Bose Shantanu, Pekny Joe, Sinclair Gavin, Keunker Kay, Bunch Paul, Risk management in the development of new products in highly regulated industries, 10.1016/s0098-1354(00)00388-4
- Boros Endre, Ünlüyurt Tonguç, 10.1023/a:1018958928835
- Butterworth Richard, Some Reliability Fault-Testing Models, 10.1287/opre.20.2.335
- Chiu Steve Y, Jr Louis A.Cox, Sun Xiaorong, Optimal sequential inspections of reliability systems subject to parallel-chain precedence constraints, 10.1016/s0166-218x(99)00097-9
- Crama Pascale, Reyck Bert De, Degraeve Zeger, Chong Wang, Research and Development Project Valuation and Licensing Negotiations at Phytopharm plc, 10.1287/inte.1060.0255
- Dahan E., Reducing technical uncertainty in product and process development through parallel design of prototypes (1998)
- Demeulemeester Erik, Vanhoucke Mario, Herroelen Willy, 10.1023/a:1022283403119
- Denardo Eric V., Rothblum Uriel G., Van der Heyden Ludo, Index Policies for Stochastic Search in a Forest with an Application to R&D Project Management, 10.1287/moor.1030.0072
- DiMasi J, Risks in new drug development: Approval success rates for investigational drugs, 10.1067/mcp.2001.115446
- Ding Ming, Eliashberg Jehoshua, Structuring the New Product Development Pipeline, 10.1287/mnsc.48.3.343.7727
- Eppinger Steven D., Whitney Daniel E., Smith Robert P., Gebala David A., A model-based method for organizing tasks in product development, 10.1007/bf01588087
- Gassmann O., Leading Pharmaceutical Innovation. Trends and Drivers for Growth in the Pharmaceutical Industry (2004)
- Granot Daniel, Zuckerman Dror, Optimal Sequencing and Resource Allocation in Research and Development Projects, 10.1287/mnsc.37.2.140
- Hagstrom Jane N., Computational complexity of PERT problems, 10.1002/net.3230180206
- Herroelen Willy, Leus Roel, Project scheduling under uncertainty: Survey and research potentials, 10.1016/j.ejor.2004.04.002
- Herroelen Willy S., Van Dommelen Patrick, Demeulemeester Erik L., Project network models with discounted cash flows a guided tour through recent developments, 10.1016/s0377-2217(96)00112-9
- Hill A. V., The Encyclopedia of Operations Management Terms (2007)
- Hoedemaker Geert M., Blackburn Joseph D., Van Wassenhove Luk N., Limits to Concurrency, 10.1111/j.1540-5915.1999.tb01599.x
- Jain Vipul, Grossmann Ignacio E., Resource-Constrained Scheduling of Tests in New Product Development, 10.1021/ie9807809
- Krishnan V., Bhattacharya Shantanu, Technology Selection and Commitment in New Product Development: The Role of Uncertainty and Design Flexibility, 10.1287/mnsc.48.3.313.7728
- Krishnan Viswanathan, Eppinger Steven D., Whitney Daniel E., A Model-Based Framework to Overlap Product Development Activities, 10.1287/mnsc.43.4.437
- Lawler E. L., Combinatorial Optimization: Networks and Matroids (1976)
- Lenstra J. K., Rinnooy Kan A. H. G., Complexity of Scheduling under Precedence Constraints, 10.1287/opre.26.1.22
- Lockett A. G., Gear A. E., Representation and Analysis of Multi-Stage Problems in R & D, 10.1287/mnsc.19.8.947
- Mastor Anthony A., An Experimental Investigation and Comparative Evaluation of Production Line Balancing Techniques, 10.1287/mnsc.16.11.728
- Mitten L. G., Journal of Industrial Engineering, 11, 17 (1960)
- Möhring R. H., Computational Discrete Mathematics, Advanced Lectures (2001)
- Monma Clyde L., Sidney Jeffrey B., Sequencing with Series-Parallel Precedence Constraints, 10.1287/moor.4.3.215
- Neumann Klaus, Schwindt Christoph, Zimmermann Jürgen, Project Scheduling with Time Windows and Scarce Resources, ISBN:9783642072659, 10.1007/978-3-540-24800-2
- Padman Rema, Smith-Daniels Dwight E., Smith-Daniels Vicki L., Heuristic scheduling of resource-constrained projects with cash flows, 10.1002/(sici)1520-6750(199706)44:4<365::aid-nav6>3.0.co;2-4
- Parker R., Discrete Optimization (1988)
- Pinedo M., Scheduling. Theory, Algorithms, and Systems (2002)
- Schmidt Craig W., Grossmann Ignacio E., Optimization Models for the Scheduling of Testing Tasks in New Product Development, 10.1021/ie9601099
- Shah Nilay, Pharmaceutical supply chains: key issues and strategies for optimisation, 10.1016/j.compchemeng.2003.09.022
- Ünlüyurt Tonguç, Sequential testing of complex systems: a review, 10.1016/j.dam.2002.08.001
- Weitzman Martin L., Optimal Search for the Best Alternative, 10.2307/1910412
- Zemel Amos, David Israel, Mehrez Abraham, On Conducting Simultaneous Versus Sequential Engineering Activities in Risky R&D, 10.1111/1475-3995.00335
- Zipfel A., Drug Information Journal, 37, 185 (2003)
Bibliographic reference |
De Reyck, Bert ; Leus, Roel. R&D project scheduling when activities may fail. In: IIE Transactions : industrial engineering research & development, Vol. 40, no. 4, p. 367-384 (2008) |
Permanent URL |
http://hdl.handle.net/2078.1/36987 |