Raina, Sheetal
De Vizio, Daniela
Odell, Mark
Clements, Mark
Vanhulle, Sophie
[UCL]
Keshavarz, Tajalli
Inter-cell communication aided by released chemical signals when cell density reaches a critical concentration has been investigated for over 30 years as quorum sensing. Originally discovered in Gram-negative bacteria, quorum-sensing systems have also been studied extensively in Gram-positive bacteria and dimorphic fungi. Microbial communities communicating via quorum sensing employ various chemical signals to supervise their surrounding environment, alter genetic expression and gain advantage over their competitors. These signals vary from acylhomoserine lactones to small modified or unmodified peptides to complex gamma-butyrolactone molecules. The scope of this review is to give an insight into some of the quorum-sensing systems now known and to explore their role in microbial physiology and development of pathogenesis. Particular attention will be dedicated to the signalling molecules involved in quorum-sensing-mediated processes and the potential shown by some of their natural and synthetic analogues in the treatment of infections triggered by quorum sensing.
- Fuqua W, J. Bacteriol., 176, 269 (1994)
- Nealson K, J. Bacteriol., 104, 313 (1970)
- Greenberg E. Peter, Bacterial communication and group behavior, 10.1172/jci200320099
- Surette M. G., Bassler B. L., Quorum sensing in Escherichia coli and Salmonella typhimurium, 10.1073/pnas.95.12.7046
- Swift S, Adv. Microb. Physiol., 45, 199 (2001)
- Eberhard A., Burlingame A. L., Eberhard C., Kenyon G. L., Nealson K. H., Oppenheimer N. J., Structural identification of autoinducer of Photobacterium fischeri luciferase, 10.1021/bi00512a013
- Engebrecht Joanne, Nealson Kenneth, Silverman Michael, Bacterial bioluminescence: Isolation and genetic analysis of functions from Vibrio fischeri, 10.1016/0092-8674(83)90063-6
- Withers Helen, Swift Simon, Williams Paul, Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria, 10.1016/s1369-5274(00)00187-9
- Miller Melissa B., Bassler Bonnie L., Quorum Sensing in Bacteria, 10.1146/annurev.micro.55.1.165
- Bassler Bonnie L, How bacteria talk to each other: regulation of gene expression by quorum sensing, 10.1016/s1369-5274(99)00025-9
- Kleerebezem Michiel, Quadri Luis E. N., Kuipers Oscar P., de Vos Willem M., Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria, 10.1046/j.1365-2958.1997.4251782.x
- Bassler Bonnie L, Small Talk, 10.1016/s0092-8674(02)00749-3
- Parkinson J
- Dunny Gary M., Leonard Bettina A. B., CELL-CELL COMMUNICATION IN GRAM-POSITIVE BACTERIA, 10.1146/annurev.micro.51.1.527
- Miller V L, Mekalanos J J, A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR., 10.1128/jb.170.6.2575-2583.1988
- Gambello M, J. Bacteriol., 173, 3000 (1991)
- Throup John P., Camara Miguel, Briggs Geoffrey S., Winson Michael. K., Chhabra Siri Ram, Bycroft Barrie W., Williams Paul, Stewart Gordon S.A.B., Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two N-acylhomoserine lactone signal molecules, 10.1111/j.1365-2958.1995.mmi_17020345.x
- Pesci E, J. Bacteriol., 179, 3127 (1997)
- Lewenza S, J. Bacteriol., 181, 748 (1999)
- Passador L, Cook J., Gambello M., Rust L, Iglewski B., Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication, 10.1126/science.8493556
- Winson M. K., Camara M., Latifi A., Foglino M., Chhabra S. R., Daykin M., Bally M., Chapon V., Salmond G. P., Bycroft B. W., Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa., 10.1073/pnas.92.20.9427
- Davies D. G., The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm, 10.1126/science.280.5361.295
- Yoon Sang Sun, Hennigan Robert F., Hilliard George M., Ochsner Urs A., Parvatiyar Kislay, Kamani Moneesha C., Allen Holly L., DeKievit Teresa R., Gardner Paul R., Schwab Ute, Rowe John J., Iglewski Barbara H., McDermott Timothy R., Mason Ronald P., Wozniak Daniel J., Hancock Robert E.W., Parsek Matthew R., Noah Terry L., Boucher Richard C., Hassett Daniel J., Pseudomonas aeruginosa Anaerobic Respiration in Biofilms, 10.1016/s1534-5807(02)00295-2
- Hentzer Morten, Eberl Leo, Nielsen John, Givskov Michael, Quorum Sensing : A Novel Target for the Treatment of Biofilm Infections, 10.2165/00063030-200317040-00003
- Wagner V. E., Bushnell D., Passador L., Brooks A. I., Iglewski B. H., Microarray Analysis of Pseudomonas aeruginosa Quorum-Sensing Regulons: Effects of Growth Phase and Environment, 10.1128/jb.185.7.2080-2095.2003
- Schuster M., Lostroh C. P., Ogi T., Greenberg E. P., Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis, 10.1128/jb.185.7.2066-2079.2003
- Whiteley M., Lee K. M., Greenberg E. P., Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa, 10.1073/pnas.96.24.13904
- Hentzer M
- Gambello M, Infect. Immun., 61, 1180 (1993)
- Pearson J. P., Gray K. M., Passador L., Tucker K. D., Eberhard A., Iglewski B. H., Greenberg E. P., Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes., 10.1073/pnas.91.1.197
- Latifi A., Foglino M., Tanaka K., Williams P., Lazdunski A., A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhlR (VsmR) to expression of the stationary-phase sigma factor RpoS, 10.1046/j.1365-2958.1996.00063.x
- Ochsner U, J. Biol. Chem., 269, 19787 (1994)
- Ochsner U. A., Reiser J., Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa., 10.1073/pnas.92.14.6424
- Pearson J. P., Passador L., Iglewski B. H., Greenberg E. P., A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa., 10.1073/pnas.92.5.1490
- Ochsner U, J. Bacteriol., 176, 2044 (1994)
- Cabrol S., Olliver A., Pier G. B., Andremont A., Ruimy R., Transcription of Quorum-Sensing System Genes in Clinical and Environmental Isolates of Pseudomonas aeruginosa, 10.1128/jb.185.24.7222-7230.2003
- Smith E. E., Buckley D. G., Wu Z., Saenphimmachak C., Hoffman L. R., D'Argenio D. A., Miller S. I., Ramsey B. W., Speert D. P., Moskowitz S. M., Burns J. L., Kaul R., Olson M. V., Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients, 10.1073/pnas.0602138103
- Duan K., Surette M. G., Environmental Regulation of Pseudomonas aeruginosa PAO1 Las and Rhl Quorum-Sensing Systems, 10.1128/jb.00043-07
- Venturi Vittorio, Regulation of quorum sensing inPseudomonas, 10.1111/j.1574-6976.2005.00012.x
- Tang H, Infect. Immun., 64, 37 (1996)
- Rumbaugh K, Infect. Immun., 67, 5854 (1999)
- Wu Hong, Heydorn Arne, Eberl Leo, Song Zhijun, Hentzer Morten, Molin Søren, Givskov Michael, Moser Claus, Mathee Kalai, Høiby Niels, Andersen Jens Bo, Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa, 10.1099/00221287-146-10-2481
- Tan M.-W., Mahajan-Miklos S., Ausubel F. M., Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis, 10.1073/pnas.96.2.715
- Rumbaugh Kendra P., Diggle Stephen P., Watters Chase M., Ross-Gillespie Adin, Griffin Ashleigh S., West Stuart A., Quorum Sensing and the Social Evolution of Bacterial Virulence, 10.1016/j.cub.2009.01.050
- Chugani S. A., Whiteley M., Lee K. M., D'Argenio D., Manoil C., Greenberg E. P., QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa, 10.1073/pnas.051624298
- Ledgham Fouzia, Ventre Isabelle, Soscia Chantal, Foglino Maryline, Sturgis James N., Lazdunski Andrée, Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR : Interactions of QscR, 10.1046/j.1365-2958.2003.03423.x
- Juhas M., Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa, 10.1099/mic.0.26906-0
- Diggle Stephen P., Winzer Klaus, Chhabra Siri Ram, Worrall Kathryn E., Cámara Miguel, Williams Paul, The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR : PQS regulation of rhl-dependent phenotypes, 10.1046/j.1365-2958.2003.03672.x
- Pesci E. C., Milbank J. B. J., Pearson J. P., McKnight S., Kende A. S., Greenberg E. P., Iglewski B. H., Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa, 10.1073/pnas.96.20.11229
- Smith Roger S., Iglewski Barbara H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, 10.1172/jci200320364
- TATEDA Kazuhiro, ISHII Yoshikazu, YAMAGUCHI Keizo, , 10.3412/jsb.59.543
- Giacometti A., Cirioni O., Gov Y., Ghiselli R., Del Prete M. S., Mocchegiani F., Saba V., Orlando F., Scalise G., Balaban N., Dell'Acqua G., RNA III Inhibiting Peptide Inhibits In Vivo Biofilm Formation by Drug-Resistant Staphylococcus aureus, 10.1128/aac.47.6.1979-1983.2003
- Lowy Franklin D., Staphylococcus aureusInfections, 10.1056/nejm199808203390806
- Mehlin Christopher, Headley Catherine M., Klebanoff Seymour J., An Inflammatory Polypeptide Complex fromStaphylococcus epidermidis: Isolation and Characterization, 10.1084/jem.189.6.907
- Balaban N., Novick R. P., Autocrine regulation of toxin synthesis by Staphylococcus aureus., 10.1073/pnas.92.5.1619
- Morfeldt E, EMBO J., 14, 4569 (1995)
- Novick R. P., Projan S. J., Kornblum J., Ross H. F., Ji G., Kreiswirth B., Vandenesch F., Moghazeh S., Novick R. P., Theagr P2 operon: An autocatalytic sensory transduction system inStaphylococcus aureus, 10.1007/bf02191645
- Ji G., Beavis R. C., Novick R. P., Cell density control of staphylococcal virulence mediated by an octapeptide pheromone., 10.1073/pnas.92.26.12055
- Mayville P., Ji G., Beavis R., Yang H., Goger M., Novick R. P., Muir T. W., Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence, 10.1073/pnas.96.4.1218
- Otto Michael, Süßmuth Roderich, Jung Günther, Götz Friedrich, Structure of the pheromone peptide of theStaphylococcus epidermidis agrsystem, 10.1016/s0014-5793(98)00145-8
- Saenz Henri L., Augsburger Vera, Vuong Cuong, Jack Ralph W., Götz Friedrich, Otto Michael, Inducible expression and cellular location of AgrB, a protein involved in the maturation of the staphylococcal quorum-sensing pheromone, 10.1007/s002030000223
- Zhang Linsheng, Lin Jianqun, Ji Guangyong, Membrane Anchoring of the AgrD N-terminal Amphipathic Region Is Required for Its Processing to Produce a Quorum-sensing Pheromone inStaphylococcus aureus, 10.1074/jbc.m311349200
- Otto Michael, Süßmuth Roderich, Vuong Cuong, Jung Günther, Götz Friedrich, Inhibition of virulence factor expression inStaphylococcus aureusby theStaphylococcus epidermidisagr pheromone and derivatives, 10.1016/s0014-5793(99)00514-1
- Koenig R. L., Ray J. L., Maleki S. J., Smeltzer M. S., Hurlburt B. K., Staphylococcus aureus AgrA Binding to the RNAIII-agr Regulatory Region, 10.1128/jb.186.22.7549-7555.2004
- Huntzinger Eric, Boisset Sandrine, Saveanu Cosmin, Benito Yvonne, Geissmann Thomas, Namane Abdelkader, Lina Gérard, Etienne Jerome, Ehresmann Bernard, Ehresmann Chantal, Jacquier Alain, Vandenesch François, Romby Pascale, Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression, 10.1038/sj.emboj.7600572
- Novick Richard P., Geisinger Edward, Quorum Sensing in Staphylococci, 10.1146/annurev.genet.42.110807.091640
- Novick Richard P., Autoinduction and signal transduction in the regulation of staphylococcal virulence : Regulation of staphylococcus virulence, 10.1046/j.1365-2958.2003.03526.x
- Otto Michael, Quorum-sensing control in Staphylococci â a target for antimicrobial drug therapy?, 10.1016/j.femsle.2004.11.016
- Vuong Cuong, Dürr Manuela, Carmody Aaron B., Peschel Andreas, Klebanoff Seymour J., Otto Michael, Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermidis: quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins : Quorum sensing control of inflammation in S. epidermidis, 10.1111/j.1462-5822.2004.00401.x
- Yang G, Inhibition of Staphylococcus aureus pathogenesis in vitro and in vivo by RAP-binding peptides, 10.1016/j.peptides.2003.09.017
- Yarwood J. M., Bartels D. J., Volper E. M., Greenberg E. P., Quorum Sensing in Staphylococcus aureus Biofilms, 10.1128/jb.186.6.1838-1850.2004
- Klapwijk P, J. Bacteriol., 136, 775 (1978)
- Ellis J. G., Kerr A., Petit A., Tempe J., Conjugal transfer of nopaline and agropine Ti-plasmids ?The role of agrocinopines, 10.1007/bf00331861
- Habeeb Linda F., Transcription of the Octopine Catabolism Operon of theAgrobacteriumTumor-Inducing Plasmid pTiA6 Is Activated by a LysR-Type Regulatory Protein, 10.1094/mpmi-4-379
- Wang Lu, Helmann John D., Winans Stephen C., The A. tumefaciens transcriptional activator OccR causes a bend at a target promoter, which is partially relaxed by a plant tumor metabolite, 10.1016/0092-8674(92)90229-6
- Fuqua Clay, Winans Stephen C., Localization of OccR-activated and TraR-activated promoters that express two ABC-type permeases and the traR gene of Ti plasmid pTiR10, 10.1111/j.1365-2958.1996.tb02640.x
- Piper Kevin R., Beck von Bodman Susanne, Hwang Ingyu, Farrand Stephen K., Hierarchical gene regulatory systems arising from fortuitous gene associations: controlling quorum sensing by the opine regulon in Agrobacterium, 10.1046/j.1365-2958.1999.01422.x
- More M. I., Finger L. D., Stryker J. L., Fuqua C., Eberhard A., Winans S. C., Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined Substrates, 10.1126/science.272.5268.1655
- Beck von Bodman S., Hayman G. T., Farrand S. K., Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor., 10.1073/pnas.89.2.643
- Kim H, J. Bacteriol., 179, 7559 (1997)
- Fuqua C, J. Bacteriol., 177, 1367 (1995)
- Hwang I, J. Bacteriol., 177, 449 (1995)
- Hwang Ingyu, Smyth Audra J., Luo Zhao-Qing, Farrand Stephen K., Modulating quorum sensing by antiactivation: TraM interacts with TraR to inhibit activation of Ti plasmid conjugal transfer genes, 10.1046/j.1365-2958.1999.01595.x
- Luo Zhao-Qing, Qin Yinping, Farrand Stephen K., The Antiactivator TraM Interferes with the Autoinducer-dependent Binding of TraR to DNA by Interacting with the C-terminal Region of the Quorum-sensing Activator, 10.1074/jbc.275.11.7713
- Piper K. R., Farrand S. K., Quorum Sensing but Not Autoinduction of Ti Plasmid Conjugal Transfer Requires Control by the Opine Regulon and the Antiactivator TraM, 10.1128/jb.182.4.1080-1088.2000
- Perombelon M C M, Kelman A, Ecology of the Soft Rot Erwinias, 10.1146/annurev.py.18.090180.002045
- Demain A, Int. Microbiol., 1, 259 (1998)
- Quadri Luis E.N., 10.1023/a:1020624808520
- Vandenbergh Peter A., Lactic acid bacteria, their metabolic products and interference with microbial growth, 10.1111/j.1574-6976.1993.tb00020.x
- Buchman G, J. Biol. Chem., 263, 16260 (1988)
- Engelke G, Appl. Environ. Microbiol., 58, 3730 (1992)
- Kaletta C, Entian K D, Nisin, a peptide antibiotic: cloning and sequencing of the nisA gene and posttranslational processing of its peptide product., 10.1128/jb.171.3.1597-1601.1989
- KUIPERS Oscar P., BEERTHUYZEN Marke M., SIEZEN Roland J., VOS Willem M., Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisIgenes for development of immunity, 10.1111/j.1432-1033.1993.tb18143.x
- Siegers K, Appl. Environ. Microbiol., 61, 1082 (1995)
- van der Meer J, J. Bacteriol., 175, 2578 (1993)
- Engelke G, Appl. Environ. Microbiol., 60, 814 (1994)
- Stock Jeffry B., Stock Ann M., Mottonen James M., Signal transduction in bacteria, 10.1038/344395a0
- Parkinson John S., Kofoid Eric C., Communication Modules in Bacterial Signaling Proteins, 10.1146/annurev.ge.26.120192.000443
- Wanner B, J. Bacteriol., 174, 2053 (1992)
- Gross E, Hoppe-Seylers Z. Physiol. Chem., 354, 799 (1973)
- Gutowski-Eckel Z, Appl. Environ. Microbiol., 60, 1 (1994)
- Klein C, Appl. Environ. Microbiol., 59, 296 (1993)
- McGowan Simon J., Holden Matthew T. G., Bycroft Barrie W., Salmond George P. C., 10.1023/a:1001768428383
- Salmond G. P. C., Bycroft B. W., Stewart G. S. A. B., Williams P., The bacterial 'enigma': cracking the code of cell?cell communication, 10.1111/j.1365-2958.1995.tb02424.x
- Bibb Mervyn J, Regulation of secondary metabolism in streptomycetes, 10.1016/j.mib.2005.02.016
- Collmer A, Keen N T, The Role of Pectic Enzymes in Plant Pathogenesis, 10.1146/annurev.py.24.090186.002123
- Byers J. T., Lucas C., Salmond G. P. C., Welch M., Nonenzymatic Turnover of an Erwinia carotovora Quorum-Sensing Signaling Molecule, 10.1128/jb.184.4.1163-1171.2002
- Jones S, EMBO J., 12, 2477 (1993)
- Fineran P, Mol. Microbiol., 56, 1495 (2005)
- Gerber Nancy N., Lechevalier Mary P., Phenazines and Phenoxaziones from Waksmania aerata sp. nov. and Pseudomonas iodina*, 10.1021/bi00892a022
- Karnetová J., Tax J., Stajner K., Vaněk Z., Krumphanzl V., Production of phenazines byStreptomyces cinnamonensis, 10.1007/bf02877385
- Giddens Stephen R., Bean David C., Investigations into the in vitro antimicrobial activity and mode of action of the phenazine antibiotic d-alanylgriseoluteic acid, 10.1016/j.ijantimicag.2006.08.028
- Pierson III Leland S., Cloning and Heterologous Expression of the Phenazine Biosynthetic Locus fromPseudomonas aureofaciens30-84, 10.1094/mpmi-5-330
- Wood D, J. Bacteriol., 179, 7663 (1997)
- Chin-A-Woeng Thomas F. C., Bloemberg Guido V., Mulders Ine H. M., Dekkers Linda C., Lugtenberg Ben J. J., Root Colonization by Phenazine-1-Carboxamide-Producing BacteriumPseudomonas chlororaphisPCL1391 Is Essential for Biocontrol of Tomato Foot and Root Rot, 10.1094/mpmi.2000.13.12.1340
- Chin-A-Woeng Thomas F. C., van den Broek Daan, de Voer Gert, van der Drift Koen M. G. M., Tuinman Sietske, Thomas-Oates Jane E., Lugtenberg Ben J. J., Bloemberg Guido V., Phenazine-1-Carboxamide Production in the Biocontrol StrainPseudomonas chlororaphisPCL1391 Is Regulated by Multiple Factors Secreted into the Growth Medium, 10.1094/mpmi.2001.14.8.969
- Horinouchi S, Beppu T, Autoregulatory Factors and Communication in Actinomycetes, 10.1146/annurev.mi.46.100192.002113
- Miyake K, J. Bacteriol., 171, 4298 (1989)
- Recio E., Colinas A., Rumbero A., Aparicio J. F., Martin J. F., PI Factor, a Novel Type Quorum-sensing Inducer Elicits Pimaricin Production in Streptomyces natalensis, 10.1074/jbc.m402340200
- OHNISHI Yasuo, YAMAZAKI Haruka, KATO Jun-ya, TOMONO Ayami, HORINOUCHI Sueharu, AdpA, a Central Transcriptional Regulator in the A-Factor Regulatory Cascade That Leads to Morphological Development and Secondary Metabolism inStreptomyces griseus, 10.1271/bbb.69.431
- Natsume Ryo, Ohnishi Yasuo, Senda Toshiya, Horinouchi Sueharu, Crystal Structure of a γ-Butyrolactone Autoregulator Receptor Protein in Streptomyces coelicolor A3(2), 10.1016/j.jmb.2003.12.040
- Nihira T
- Kitani S., Yamada Y., Nihira T., Gene Replacement Analysis of the Butyrolactone Autoregulator Receptor (FarA) Reveals that FarA Acts as a Novel Regulator in Secondary Metabolism of Streptomyces lavendulae FRI-5, 10.1128/jb.183.14.4357-4363.2001
- Takano Eriko, Chakraburtty Rekha, Nihira Takuya, Yamada Yashuhiro, Bibb Mervyn J., A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2) : γ-Butyrolactones and antibiotic production, 10.1046/j.1365-2958.2001.02562.x
- Wietzorrek Andreas, Bibb Mervyn, A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold, 10.1046/j.1365-2958.1997.5421903.x
- Recio E., Glycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetes, 10.1099/mic.0.28953-0
- Anton N., Mendes M. V., Martin J. F., Aparicio J. F., Identification of PimR as a Positive Regulator of Pimaricin Biosynthesis in Streptomyces natalensis, 10.1128/jb.186.9.2567-2575.2004
- Marketon M. M., Glenn S. A., Eberhard A., Gonzalez J. E., Quorum Sensing Controls Exopolysaccharide Production in Sinorhizobium meliloti, 10.1128/jb.185.1.325-331.2003
- von Bodman S. B., Majerczak D. R., Coplin D. L., A negative regulator mediates quorum-sensing control of exopolysaccharide production in Pantoea stewartii subsp. stewartii, 10.1073/pnas.95.13.7687
- Xavier Karina B., Bassler Bonnie L., Interference with AI-2-mediated bacterial cell–cell communication, 10.1038/nature03960
- Bassler B, J. Bacteriol., 179, 4043 (1997)
- Surette M. G., Miller M. B., Bassler B. L., Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production, 10.1073/pnas.96.4.1639
- Schauder Stephan, Shokat Kevan, Surette Michael G., Bassler Bonnie L., The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule : AI-2 biosynthesis, 10.1046/j.1365-2958.2001.02532.x
- Bassler Bonnie L., Wright Miriam, Silverman Michael R., Multiple signalling systems controlling expression of luminescence in Vibrio harveyi
: sequence and function of genes encoding a second sensory pathway, 10.1111/j.1365-2958.1994.tb00422.x
- Bassler Bonnie L., Wright Miriam, Silverman Michael R., Sequence and function of LuxO, a negative regulator of luminescence in Vibrio harveyi, 10.1111/j.1365-2958.1994.tb01029.x
- Freeman Jeremy A., Bassler Bonnie L., A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi, 10.1046/j.1365-2958.1999.01208.x
- Martin M, Showalter R, Silverman M, Identification of a locus controlling expression of luminescence genes in Vibrio harveyi., 10.1128/jb.171.5.2406-2414.1989
- Showalter R, J. Bacteriol., 172, 2946 (1990)
- Long Tao, Tu Kimberly C, Wang Yufang, Mehta Pankaj, Ong N. P, Bassler Bonnie L, Wingreen Ned S, Quantifying the Integration of Quorum-Sensing Signals with Single-Cell Resolution, 10.1371/journal.pbio.1000068
- Wang L., Li J., March J. C., Valdes J. J., Bentley W. E., luxS-Dependent Gene Regulation in Escherichia coli K-12 Revealed by Genomic Expression Profiling, 10.1128/jb.187.24.8350-8360.2005
- DeLisa M. P., Wu C.-F., Wang L., Valdes J. J., Bentley W. E., DNA Microarray-Based Identification of Genes Controlled by Autoinducer 2-Stimulated Quorum Sensing in Escherichia coli, 10.1128/jb.183.18.5239-5247.2001
- Sperandio V., Mellies J. L., Nguyen W., Shin S., Kaper J. B., Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli, 10.1073/pnas.96.26.15196
- Burgess Nicola A., Aduse-Opoku Joseph, Cámara Miguel, Winzer Klaus, Williams Paul, Meyers Nicholas L., Curtis Michael A., Kirke David F., Hardie Kim R., LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence, 10.1099/00221287-148-3-763
- Chung W. O., Park Y., Lamont R. J., McNab R., Barbieri B., Demuth D. R., Signaling System in Porphyromonas gingivalis Based on a LuxS Protein, 10.1128/jb.183.13.3903-3909.2001
- Fong K. P., Chung W. O., Lamont R. J., Demuth D. R., Intra- and Interspecies Regulation of Gene Expression by Actinobacillus actinomycetemcomitans LuxS, 10.1128/iai.69.12.7625-7634.2001
- McNab R., Ford S. K., El-Sabaeny A., Barbieri B., Cook G. S., Lamont R. J., LuxS-Based Signaling in Streptococcus gordonii: Autoinducer 2 Controls Carbohydrate Metabolism and Biofilm Formation with Porphyromonas gingivalis, 10.1128/jb.185.1.274-284.2003
- Taga Michiko E., Semmelhack Julia L., Bassler Bonnie L., The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium : Autoinducer-dependent gene regulation, 10.1046/j.1365-2958.2001.02669.x
- Taga Michiko E., Miller Stephen T., Bassler Bonnie L., Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium : Transport and processing of AI-2, 10.1046/j.1365-2958.2003.03781.x
- Miller Melissa B., Skorupski Karen, Lenz Derrick H., Taylor Ronald K., Bassler Bonnie L., Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae, 10.1016/s0092-8674(02)00829-2
- Zhu J., Miller M. B., Vance R. E., Dziejman M., Bassler B. L., Mekalanos J. J., Quorum-sensing regulators control virulence gene expression in Vibrio cholerae, 10.1073/pnas.052694299
- Finkelstein R, Infect. Immun., 60, 472 (1992)
- Lyon William R., Madden John C., Levin James C., Stein Jeffrey L., Caparon Michael G., Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes : The effect of LuxS on virulence factors in S. pyogenes, 10.1046/j.1365-2958.2001.02616.x
- Ohtani Kaori, Hayashi Hideo, Shimizu Tohru, The luxS gene is involved in cell-cell signalling for toxin production in Clostridium perfringens : luxS gene function in C. perfringens toxin production, 10.1046/j.1365-2958.2002.02863.x
- Jones M. B., Blaser M. J., Detection of a luxS-Signaling Molecule in Bacillus anthracis, 10.1128/iai.71.7.3914-3919.2003
- Auger S., Krin E., Aymerich S., Gohar M., Autoinducer 2 Affects Biofilm Formation by Bacillus cereus, 10.1128/aem.72.1.937-941.2006
- Hilgers M. T., Ludwig M. L., Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site, 10.1073/pnas.191223098
- Ruzheinikov S.N, Das S.K, Sedelnikova S.E, Hartley A, Foster S.J, Horsburgh M.J, Cox A.G, McCleod C.W, Mekhalfia A, Blackburn G.M, Rice D.W, Baker P.J, The 1.2 Å structure of a novel quorum-sensing protein, Bacillus subtilis LuxS 1 1Edited by J. Thornton, 10.1006/jmbi.2001.5027
- Winzer K, Bacterial cell-to-cell communication: sorry, can't talk now — gone to lunch!, 10.1016/s1369-5274(02)00304-1
- Pei Dehua, Zhu Jinge, Mechanism of action of S-ribosylhomocysteinase (LuxS), 10.1016/j.cbpa.2004.08.003
- Lombardia E., Rovetto A. J., Arabolaza A. L., Grau R. R., A LuxS-Dependent Cell-to-Cell Language Regulates Social Behavior and Development in Bacillus subtilis, 10.1128/jb.00165-06
- Chu Frances, Kearns Daniel B., Branda Steven S., Kolter Roberto, Losick Richard, Targets of the master regulator of biofilm formation in Bacillus subtilis, 10.1111/j.1365-2958.2005.05019.x
- Hamon Mélanie A., Lazazzera Beth A., The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis : Biofilm development in Bacillus subtilis, 10.1046/j.1365-2958.2001.02709.x
- Hartman Giles, Wise Richard, Quorum sensing: potential means of treating gram-negative infections?, 10.1016/s0140-6736(05)70282-8
- Hentzer Morten, Givskov Michael, Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, 10.1172/jci20074
- Riedel Kathrin, Steidle Anette, Eberl Leo, Wu Hong, Geisenberger Otto, Molin Søren, Huber Birgit, Hentzer Morten, Høiby Niels, Givskov Michael, N-Acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms, 10.1099/00221287-147-12-3249
- Roche D. M., Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?, 10.1099/mic.0.26977-0
- Dong Y.-H., Gusti A. R., Zhang Q., Xu J.-L., Zhang L.-H., Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species, 10.1128/aem.68.4.1754-1759.2002
- Leadbetter J. R., Greenberg E. P., Metabolism of Acyl-Homoserine Lactone Quorum-Sensing Signals by Variovorax paradoxus, 10.1128/jb.182.24.6921-6926.2000
- Liu Dali, Momb Jessica, Thomas Pei W., Moulin Aaron, Petsko Gregory A., Fast Walter, Ringe Dagmar, Mechanism of the Quorum-Quenching Lactonase (AiiA) fromBacillus thuringiensis. 1. Product-Bound Structures†‡, 10.1021/bi800368y
- Dong Y.-H., Zhang X.-F., Xu J.-L., Zhang L.-H., Insecticidal Bacillus thuringiensis Silences Erwinia carotovora Virulence by a New Form of Microbial Antagonism, Signal Interference, 10.1128/aem.70.2.954-960.2004
- Xu Xiao-Hong Nancy, Wan Qian, Kyriacou Sophia V., Brownlow William J., Nowak Michelle E., Direct observation of substrate induction of resistance mechanism in Pseudomonas aeruginosa using single live cell imaging, 10.1016/s0006-291x(03)00874-x
- Smith Kristina M., Bu Yigong, Suga Hiroaki, Library Screening for Synthetic Agonists and Antagonists of a Pseudomonas aeruginosa Autoinducer, 10.1016/s1074-5521(03)00107-8
- Smith Kristina M, Bu Yigong, Suga Hiroaki, Induction and Inhibition of Pseudomonas aeruginosa Quorum Sensing by Synthetic Autoinducer Analogs, 10.1016/s1074-5521(03)00002-4
- Ikeda T, Chem. Lett., 30, 314 (2001)
- Ishida T., Ikeda T., Takiguchi N., Kuroda A., Ohtake H., Kato J., Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N-Acyl Cyclopentylamides, 10.1128/aem.02233-06
- Kim Cheoljin, Kim Jaeeun, Park Hyung-Yeon, Park Hee-Jin, Lee Joon Hee, Kim Chan Kyung, Yoon Jeyong, Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa, 10.1007/s00253-008-1474-6
- Kim C, Appl. Microbiol. Biotechnol. (2009)
- Morohoshi T., Shiono T., Takidouchi K., Kato M., Kato N., Kato J., Ikeda T., Inhibition of Quorum Sensing in Serratia marcescens AS-1 by Synthetic Analogs of N-Acylhomoserine Lactone, 10.1128/aem.00593-07
- Swift S, Infect. Immun., 67, 5192 (1999)
- Qin Yinping, Luo Zhao-Qing, Farrand Stephen K., Domains Formed within the N-terminal Region of the Quorumsensing Activator TraR Are Required for Transcriptional Activation and Direct Interaction with RpoA fromAgrobacterium, 10.1074/jbc.m405299200
- Zhu J, J. Bacteriol., 180, 5398 (1998)
- Reverchon Sylvie, Chantegrel Bernard, Deshayes Christian, Doutheau Alain, Cotte-Pattat Nicole, New synthetic analogues of N -acyl homoserine lactones as agonists or antagonists of transcriptional regulators involved in bacterial quorum sensing, 10.1016/s0960-894x(02)00124-5
- Manefield M., de Nys R., Naresh K., Roger R., Givskov M., Peter S., Kjelleberg S., Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein, 10.1099/13500872-145-2-283
- Rasmussen Thomas Bovbjerg, Andersen Jens Bo, Eberl Leo, Anthoni Uffe, Christophersen Carsten, Givskov Michael, Steinberg Peter, Manefield Michael, Kjelleberg Staffan, How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1, 10.1099/00221287-146-12-3237
- Maximilien R, de Nys R, Holmström C, Gram L, Givskov M, Crass K, Kjelleberg S, Steinberg PD, Chemical mediation of bacterial surface colonisation by secondary metabolites from the red alga Delisea pulchra, 10.3354/ame015233
- de Nys Rocky, Wright Anthony D., König Gabriele M., Sticher Otto, New halogenated furanones from the marine alga delisea pulchra (cf. fimbriata), 10.1016/s0040-4020(01)81808-1
- Givskov M, J. Bacteriol., 178, 6618 (1996)
- Daniels Ruth, Vanderleyden Jos, Michiels Jan, Quorum sensing and swarming migration in bacteria, 10.1016/j.femsre.2003.09.004
- Lindum P, J. Bacteriol., 180, 6384 (1998)
- Manefield Michael, Steinberg Peter, Rasmussen Thomas Bovbjerg, Henzter Morten, Kjelleberg Staffan, Givskov Michael, Andersen Jens Bo, Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover, 10.1099/00221287-148-4-1119
- Gram L, Appl. Environ. Microbiol., 62, 4284 (1996)
- Ren Dacheng, Sims James J., Wood Thomas K., Inhibition of biofilm formation and swarming of Escherichia coli by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone, 10.1046/j.1462-2920.2001.00249.x
- Ren D., Zuo R., Gonzalez Barrios A. F., Bedzyk L. A., Eldridge G. R., Pasmore M. E., Wood T. K., Differential Gene Expression for Investigation of Escherichia coli Biofilm Inhibition by Plant Extract Ursolic Acid, 10.1128/aem.71.7.4022-4034.2005
- Hjelmgaard Thomas, Persson Tobias, Rasmussen Thomas B, Givskov Michael, Nielsen John, Synthesis of furanone-Based natural product analogues with quorum sensing antagonist activity, 10.1016/s0968-0896(03)00295-5
- Lonn-Stensrud J., Landin M. A., Benneche T., Petersen F. C., Scheie A. A., Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?, 10.1093/jac/dkn501
- Wu H., Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice, 10.1093/jac/dkh223
- Martinelli Daniel, Grossmann Gilles, Séquin Urs, Brandl Helmut, Bachofen Reinhard, 10.1186/1471-2180-4-25
- Gonzalez J. E., Marketon M. M., Quorum Sensing in Nitrogen-Fixing Rhizobia, 10.1128/mmbr.67.4.574-592.2003
- Loh John, Pierson Elizabeth A, Pierson Leland S, Stacey Gary, Chatterjee Arun, Quorum sensing in plant-associated bacteria, 10.1016/s1369-5266(02)00274-1
- Fray Rupert G., Throup John P., Daykin Mavis, Wallace Andrew, Williams Paul, Stewart Gordon S.A.B., Grierson Donald, 10.1038/13717
- Mäe Andres, Montesano Marcos, Koiv Viia, Palva E. Tapio, Transgenic Plants Producing the Bacterial PheromoneN-Acyl-Homoserine Lactone Exhibit Enhanced Resistance to the Bacterial PhytopathogenErwinia carotovora, 10.1094/mpmi.2001.14.9.1035
- Toth I. K., Newton J. A., Hyman L. J., Lees A. K., Daykin M., Ortori C., Williams P., Fray R. G., Potato Plants Genetically Modified to ProduceN-Acylhomoserine Lactones Increase Susceptibility to Soft Rot Erwiniae, 10.1094/mpmi.2004.17.8.880
- Dong Yi-Hu, Wang Lian-Hui, Xu Jin-Ling, Zhang Hai-Bao, Zhang Xi-Fen, Zhang Lian-Hui, Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase, 10.1038/35081101
- Zhou Yi, Choi Yong-Lark, Sun Ming, Yu Ziniu, Novel roles of Bacillus thuringiensis to control plant diseases, 10.1007/s00253-008-1610-3
- Horowitz Brown S., Zarnowski R., Sharpee W. C., Keller N. P., Morphological Transitions Governed by Density Dependence and Lipoxygenase Activity in Aspergillus flavus, 10.1128/aem.00565-08
- Raina S
- Keller Laurent, Surette Michael G., Communication in bacteria: an ecological and evolutionary perspective, 10.1038/nrmicro1383
- Diggle S. P, Gardner A., West S. A, Griffin A. S, Evolutionary theory of bacterial quorum sensing: when is a signal not a signal?, 10.1098/rstb.2007.2049
- Swift S, J. Bacteriol., 179, 5271 (1997)
- McGowan S., Sebaihia M., Jones S., Yu B., Bainton N., Chan P. F., Bycroft B., Stewart G.S.A.B., Williams P., Salmond G. P. C., Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator, 10.1099/13500872-141-3-541
- Pearson J, J. Bacteriol., 179, 5756 (1997)
Bibliographic reference |
Raina, Sheetal ; De Vizio, Daniela ; Odell, Mark ; Clements, Mark ; Vanhulle, Sophie ; et. al. Microbial quorum sensing: a tool or a target for antimicrobial therapy?. In: Biotechnology and Applied Biochemistry, Vol. 54, p. 65-84 (2009) |
Permanent URL |
http://hdl.handle.net/2078.1/35236 |