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Experimental determination of the radial dose distribution in high gradient regions around Ir-192 wires : comparison of electron paramagnetic resonance imaging, films, and Monte Carlo simulations

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Kolbun, Natallia [UCL] Levêque, Philippe [UCL] Abboud, Fadi [UCL] Bol, Anne [UCL] Vynckier, Stefaan [UCL] Gallez, Bernard [UCL]

Purpose: The experimental determination of doses at proximal distances from radioactive sources is difficult because of the steepness of the dose gradient. The goal of this study was to determine the relative radial dose distribution for a low dose rate Ir-192 wire source using electron paramagnetic resonance imaging (EPRI) and to compare the results to those obtained using Gafchromic EBT film dosimetry and Monte Carlo (MC) simulations. Methods: Lithium formate and ammonium formate were chosen as the EPR dosimetric materials and were used to form cylindrical phantoms. The dose distribution of the stable radiation-induced free radicals in the lithium formate and ammonium formate phantoms was assessed by EPRI. EBT films were also inserted inside in ammonium formate phantoms for comparison. MC simulation was performed using the MCNP4C2 software code. Results: The radical signal in irradiated ammonium formate is contained in a single narrow EPR line, with an EPR peak-to-peak linewidth narrower than that of lithium formate (similar to 0.64 and 1.4 mT, respectively). The spatial resolution of EPR images was enhanced by a factor of 2.3 using ammonium formate compared to lithium formate because its linewidth is about 0.75 mT narrower than that of lithium formate. The EPRI results were consistent to within 1% with those of Gafchromic EBT films and MC simulations at distances from 1.0 to 2.9 mm. The radial dose values obtained by EPRI were about 4% lower at distances from 2.9 to 4.0 mm than those determined by MC simulation and EBT film dosimetry. Conclusions: Ammonium formate is a suitable material under certain conditions for use in brachytherapy dosimetry using EPRI. In this study, the authors demonstrated that the EPRI technique allows the estimation of the relative radial dose distribution at short distances for a Ir-192 wire source. (C) 2010 American Association of Physicists in Medicine. [DOI: 10.1118/1.3488913]

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Medical Physics" - Vol. 37, no. 10, p. 5448-5455 (2010)
Peer reviewed yes
Publisher American Association of Physicists in Medicine ((United States) New-York)
issn 0094-2405
Publication status Publié
Affiliations UCL - (SLuc) Service de radiothérapie oncologique
UCL - (SLuc) Service de médecine nucléaire
UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - (SLuc) Service de radiothérapie oncologique
Keywords EPR ; EPR imaging ; Brachytherapy ; Dosimetry ; 192Ir ; Gafchromic EBT films ; Monte Carlo
Links
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Bibliographic reference Kolbun, Natallia ; Levêque, Philippe ; Abboud, Fadi ; Bol, Anne ; Vynckier, Stefaan ; et. al. Experimental determination of the radial dose distribution in high gradient regions around Ir-192 wires : comparison of electron paramagnetic resonance imaging, films, and Monte Carlo simulations. In: Medical Physics, Vol. 37, no. 10, p. 5448-5455 (2010)
Permanent URL http://hdl.handle.net/2078.1/34963