Abdallah, Radwan
Grenouillet, Pierre
Vriamont, Nicolas
[UCL]
Riant, Olivier
[UCL]
de Bellefon, Claude
A library of 117 ligands was combined with three transition metals Ru, Rh and Ir and screened with three different operating conditions for the asymmetric H-transfer reduction of acetophenone into phenylethanol. The combinatorial approach was based on evolution of a first library containing 60 ligands. For the evolution, operators such as replication, regression, cross-over and mutation were used. The study was performed with a XYZ robot and fast chiral GC analysis. Over only 4 generations, the average targeted criterion, enantioselectivity, was increased from 20% to ca. 80% for the 4(th) generation. The best results provided enantiomeric excess up to 93%.
Bibliographic reference |
Abdallah, Radwan ; Grenouillet, Pierre ; Vriamont, Nicolas ; Riant, Olivier ; de Bellefon, Claude. High Throughput Screening and Evolution of a Library of Ligands in Asymmetric H-Transfer Reduction of Acetophenone. In: Combinatorial Chemistry & High Throughput Screening, Vol. 13, no. 5, p. 393-413 (2010) |
Permanent URL |
http://hdl.handle.net/2078.1/33854 |