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A manually controlled new device for punctuate mechanical stimulation of teeth during functional magnetic resonance imaging studies

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Habre-Hallage, Pascale Hermoye, Laurent Gradkowski, Wojciech [UCL] Jacobs, Reinhilde Reychler, Hervé [UCL] Grandin, Cécile [UCL]

P>Aim To design a simple and affordable device that could apply standardized mechanical punctuate stimuli to trigger the periodontal mechanoreceptors during functional magnetic resonance imaging (fMRI). Material and Methods A new manually controlled device using von Frey monofilaments was tested on a phantom and on eight volunteers. Four block design paradigms with different timing were compared. Teeth 11, 12, 13, 21, 22, 23 and the thumb were stimulated. Results The device did not induce any artefacts in MR images. The most efficient protocol included an epoch duration of 24 s and stimuli delivered at 1 Hz. When stimulating the teeth, activations of the primary (S1) and secondary (S2) somatosensory areas were consistently obtained, either on the ipsilateral, contra-lateral or both sides. Stimulation of the thumb led to activations of the contra-lateral S1 area and either ipsilateral or contra-lateral S2 area. Conclusion The use of this innovative tool should allow to perform fMRI studies aimed to unveil the neural correlates of periodontal neural receptors, and to understand their plasticity induced by tooth loss and their eventual replacement by endosseous oral implants.

Document type Article de périodique (Journal article) – Article de recherche – Comparative Study, Journal Article
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Journal of Clinical Periodontology" - Vol. 37, no. 9, p. 863-872 (2010)
Peer reviewed yes
Publisher Wiley-Blackwell Munksgaard ((Denmark) Copenhagen V)
issn 0303-6979
e-issn 1600-051X
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - SSS/IONS - Institute of NeuroScience
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service de stomatologie et de chirurgie maxillo-faciale
UCL - (SLuc) Département d'imagerie médicale
UCL - (SLuc) Service de radiologie
MESH Subject Young Adult ; Touch Perception - physiology ; Tooth - innervation ; Time Factors ; Thumb - innervation ; Somatosensory Cortex - physiology ; Sensory Thresholds - physiology ; Physical Stimulation - instrumentation ; Phantoms, Imaging ; Periodontal Ligament - physiology ; Neural Pathways - physiology ; Middle Aged ; Mechanoreceptors - physiology ; Male ; Magnetic Resonance Imaging ; Incisor - innervation ; Image Processing, Computer-Assisted - methods ; Humans ; Female ; Equipment Design ; Echo-Planar Imaging - methods ; Cuspid - innervation ; Adult
Keywords dental ; fMRI ; MR-compatible ; periodontal mechanoreceptor ; somatosensory cortex ; stimulation device
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Bibliographic reference Habre-Hallage, Pascale ; Hermoye, Laurent ; Gradkowski, Wojciech ; Jacobs, Reinhilde ; Reychler, Hervé ; et. al. A manually controlled new device for punctuate mechanical stimulation of teeth during functional magnetic resonance imaging studies. In: Journal of Clinical Periodontology, Vol. 37, no. 9, p. 863-872 (2010)
Permanent URL http://hdl.handle.net/2078.1/33585