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Iron and the immune system

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Ward, Roberta J. [UCL] Crichton, Robert [UCL] Taylor, Deanna L [Imperial College, London] Corte, Laura Della [Università degli Studi di Firenze] Srai, Surjit K [University College, London] Dexter, David T [Imperial College, London]

Iron and immunity are closely linked: firstly by the fact that many of the genes/proteins involved in iron homoeostasis play a vital role in controlling iron fluxes such that bacteria are prevented from utilising iron for growth; secondly, cells of the innate immune system, monocytes, macrophages, microglia and lymphocytes, are able to combat bacterial insults by carefully controlling their iron fluxes, which are mediated by hepcidin and ferroportin. In addition, lymphocytes play an important role in adaptive immunity. Thirdly, a variety of effector molecules, e.g. toll-like receptors, NF-κB, hypoxia factor-1, haem oxygenase, will orchestrate the inflammatory response by mobilising a variety of cytokines, neurotrophic factors, chemokines, and reactive oxygen and nitrogen species. Pathologies, where iron loading and depletion occur, may adversely affect the ability of the cell to respond to the bacterial insult.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Journal of Neural Transmission. General Section" - Vol. 118, no. 3, p. 315-328 (2011)
Peer reviewed yes
Publisher Springer Wien (Wien,)
issn 0300-9564
Publication status Publié
Affiliations UCL - SST/IMCN - Institute of Condensed Matter and Nanosciences
UCL - SST/ELI/ELIM - Applied Microbiology
MESH Subject Toll-Like Receptors - immunology - metabolism ; Microglia - immunology - metabolism ; Macrophages - immunology - metabolism ; Iron - metabolism ; Inflammation - immunology - metabolism ; Immunity, Innate ; Immune System - immunology - metabolism ; Humans ; Homeostasis - physiology ; Cytokines - immunology - metabolism
Links
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Bibliographic reference Ward, Roberta J. ; Crichton, Robert ; Taylor, Deanna L ; Corte, Laura Della ; Srai, Surjit K ; et. al. Iron and the immune system. In: Journal of Neural Transmission. General Section, Vol. 118, no. 3, p. 315-328 (2011)
Permanent URL http://hdl.handle.net/2078.1/33346