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Lung cancer : morphological and functional approach to screening, staging and treatment planning

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Coche, Emmanuel [UCL] Lonneux, Max [UCL] Geets, Xavier [UCL]

Lung cancer is a major problem in public health and constitutes the leading cause of cancer-related mortality in the world. Lung cancer screening with low-dose computed tomography is promising but needs to overcome many difficulties, such as the large number of incidentally discovered nodules, the radiation dose delivered to the patient during a whole screening program and its cost. The ultimate target point represented by the reduction of lung cancer-related mortality needs to be proved in large, well-designed, randomized, multicenter, prospective trials. Lung cancer staging by morphological tools seems to be limited owing to the presence of metastases in normal-sized lymph nodes. In this context, multidetector computed tomography cannot be used alone but is useful in conjunction with molecular imaging and MRI. Today, flurodeoxglucose PET-CT appears to be the most accurate method for lung cancer staging and may prevent unnecessary thoracotomies. For treatment planning, flurodeoxglucose PET-CT is playing an increasing role in radiotherapy planning at the target selection and definition steps.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Future Oncology" - Vol. 6, no. 3, p. 367-380 (2010)
Peer reviewed yes
Publisher Future Medicine Ltd. ((United Kingdom) London)
issn 1479-6694
e-issn 1744-8301
Publication status Publié
Affiliations UCL - (SLuc) Service de radiologie
UCL - (SLuc) Service de radiothérapie oncologique
UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - (SLuc) Centre du cancer
UCL - (SLuc) Service de médecine nucléaire
MESH Subject Mass Screening - methods ; Male ; Lung Neoplasms - diagnosis - therapy ; Humans ; Female ; Diagnostic Imaging - methods ; Aged ; Adult
Keywords CT ; Diagnosis ; FDG-PET-CT ; Lung cancer ; Lung nodule ; MRI ; Planning ; Radiotherapy
Links
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Bibliographic reference Coche, Emmanuel ; Lonneux, Max ; Geets, Xavier. Lung cancer : morphological and functional approach to screening, staging and treatment planning. In: Future Oncology, Vol. 6, no. 3, p. 367-380 (2010)
Permanent URL http://hdl.handle.net/2078.1/30455