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Mutagenicity evaluation of azaperone in the Salmonella/microsome test.

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Duverger-van Bogaert, M Vanparys, P. Marsboom, R. De Meester, Conrad [UCL]

Azaperone was evaluated for its mutagenic potential by the Salmonella/microsome test. No mutagenic activity towards six S. typhimurium strains could be evidenced with azaperone at doses up to 2,000 micrograms/plate, either without or with metabolic activation at usual test conditions. Higher concentrations of liver post-mitochondrial fraction from Aroclor 1254 (ARO)-pretreated rats did not reveal any increase in the number of revertants towards S. typhimurium strains TA1537, TA1538 and TA98. Moreover, a plate-incorporation test with liver post-mitochondrial fractions from mice pretreated with phenobarbital (PB) and a liquid preincubation test with liver post-mitochondrial fractions from rats pretreated with ARO also failed to reveal any mutagenic action of azaperone towards S. typhimurium strain TA98. Thus, none of the tests used provided any indication of azaperone having a mutagenic action.

Document type Article de périodique (Journal article) – Journal Article
Publication date 1987
Journal information "Drug and chemical toxicology" - Vol. 10, no. 3-4, p. 329-38 (1987)
Peer reviewed yes
issn 0148-0545
Publication status Publié
Affiliation UCL
MESH Subject Azaperone - toxicity ; Butyrophenones - toxicity ; Mutagenicity Tests ; Mutagens ; Salmonella typhimurium - drug effects
Links
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Bibliographic reference Duverger-van Bogaert, M ; Vanparys, P. ; Marsboom, R. ; De Meester, Conrad. Mutagenicity evaluation of azaperone in the Salmonella/microsome test.. In: Drug and chemical toxicology, Vol. 10, no. 3-4, p. 329-38 (1987)
Permanent URL http://hdl.handle.net/2078.1/29641