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Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome.

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Michaux, Lucienne [UCL] Théate, Ivan [UCL] Wlodarska, Iwona [UCL] Stul, M. Scheiff, Jean-Marie [UCL] Deneys, Véronique [UCL] Hagemeijer, Anne [UCL] Ferrant, Augustin [UCL]

A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.

Document type Article de périodique (Journal article) – Case Reports, Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2004
Journal information "Annals of hematology" - Vol. 83, no. 9, p. 578-83 (2004)
Peer reviewed yes
issn 0939-5555
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL - MD/MINT - Département de médecine interne
MESH Subject Aged ; Chromosomes, Human - genetics ; Cyclin D1 - genetics ; DNA, Neoplasm - genetics ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lymphoma, Mantle-Cell - genetics - pathology ; Male ; Middle Aged ; Proto-Oncogene Proteins c-myc - genetics ; Translocation, Genetic - genetics ; Treatment Outcome ; Trisomy - genetics
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Bibliographic reference Michaux, Lucienne ; Théate, Ivan ; Wlodarska, Iwona ; Stul, M. ; Scheiff, Jean-Marie ; et. al. Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome.. In: Annals of hematology, Vol. 83, no. 9, p. 578-83 (2004)
Permanent URL http://hdl.handle.net/2078.1/29498