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Nontuberculous mycobacterial pulmonary infection in renal transplant recipients

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Ho, Thien Anh [UCL] Rommelaere, M. [UCL] Coche, Emmanuel [UCL] Yombi, Jean Cyr [UCL] Kanaan, Nada [UCL]

The most common presentations of nontuberculous mycobacterial infections in kidney transplant recipients (KTR) are cutaneous and disseminated diseases. Pleuropulmonary infection not associated with disseminated disease is rare. Its diagnosis can be difficult, requiring a combination of clinical, radiological, and bacteriological criteria. We report on a Mycobacterium avium complex pulmonary infection in a KTR with underlying chronic obstructive pulmonary disease. Chest computed tomography showed an excavated lesion of the right upper lobe, similar to a typical lesion of pulmonary tuberculosis. Evolution was favorable with multiple-drug therapy including rifampicin, ethambutol, and clarithromycin, along with a slight reduction in immunosuppression. We review the literature and discuss the epidemiology, diagnosis, management, and follow-up of this uncommon post-transplant complication.

Document type Article de périodique (Journal article) – Synthèse de littérature – Journal Article
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Transplant infectious disease : an official journal of the Transplantation Society." - Vol. 12, no. 2, p. 138-142 (2010)
Peer reviewed yes
Publisher Munksgaard ((Denmark) Copenhagen)
issn 1398-2273
e-issn 1399-3062
Publication status Publié
Affiliations UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
UCL - (SLuc) Service de néphrologie
UCL - (SLuc) Service de radiologie
UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - MD/MINT - Département de médecine interne
MESH Subject Tuberculosis, Pulmonary - diagnosis - drug therapy - etiology ; Treatment Outcome ; Sputum - microbiology ; Postoperative Complications - diagnosis - drug therapy - etiology ; Opportunistic Infections - diagnosis - drug therapy - etiology ; Mycobacterium avium ; Middle Aged ; Male ; Kidney Transplantation ; Immunosuppressive Agents - administration & dosage - adverse effects ; Humans ; Graft Rejection - prevention & control ; Clarithromycin - therapeutic use ; Antitubercular Agents - therapeutic use ; Anti-Bacterial Agents - therapeutic use
Keywords Mycobacterium avium complex ; Nontuberculous mycobacteria ; Pneumonia ; Renal transplantation
Links
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Bibliographic reference Ho, Thien Anh ; Rommelaere, M. ; Coche, Emmanuel ; Yombi, Jean Cyr ; Kanaan, Nada. Nontuberculous mycobacterial pulmonary infection in renal transplant recipients. In: Transplant infectious disease : an official journal of the Transplantation Society., Vol. 12, no. 2, p. 138-142 (2010)
Permanent URL http://hdl.handle.net/2078.1/28712