Jonas, Jean-Christophe
[UCL]
Chronic hyperglycemia exerts deleterious effects on glucose-induced insulin secretion by pancreatic beta cells. In 90% pancreatectomized rats, chronic hyperglycemia induces beta cell hypertrophy and loss of differentiation associated with increased expression of the early response gene c-Myc. Hyperglycemia also stimulates c-Myc expression in vivo in islets from glucose-infused rats and in vitro in cultured rat islets. This effect requires the elevation of cytosolic Ca2+ concentration produced by glucose. Our results suggest that overstimulation of c-Myc expression by chronic hyperglycemia may be the cause of beta cell hypertrophy and loss of differentiation and function observed in animal models of type 2 diabetes.
Bibliographic reference |
Jonas, Jean-Christophe. Rôle possible du gène de réponse précoce c-Myc dans la perte de différenciation et de fonction des cellules beta pancréatiques soumises à une hyperglycémie chronique.. In: Bulletin et mémoires de l'Académie royale de médecine de Belgique, Vol. 156, no. 6 Pt 2, p. 297-301 (2001) |
Permanent URL |
http://hdl.handle.net/2078.1/28239 |